Towards PErsonalised PRognosis for children with traumatic brain injury: the PEPR study protocol.

Autor:	Kooper CC; Department of Pediatrics, Emma Neuroscience Group, Emma Children's Hospital, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands c.c.kooper@amsterdamumc.nl.; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, The Netherlands., Oosterlaan J; Department of Pediatrics, Emma Neuroscience Group, Emma Children's Hospital, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands., Bruining H; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, The Netherlands.; Department of Child and Youth Psychiatry, Emma Children's Hospital, Amsterdam UMC location Vrije Universiteit Amsterdam, N=You centre, Amsterdam, Netherlands., Engelen M; Department of Pediatric Neurology, Emma Children's Hospital, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Leukodystrophy Center, Amsterdam, The Netherlands., Pouwels PJW; Amsterdam Neuroscience Research Institute, Amsterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Popma A; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.; Department of Child and Youth Psychiatry, Amsterdam University Medical Centres, Amsterdam, The Netherlands., van Woensel JBM; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.; Department of Pediatric Intensive Care Unit, Emma Children's Hospital, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Buis DR; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.; Department of Neurosurgery, Emma Children's Hospital, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Steenweg ME; Department of Pediatric Neurology, OLVG, Amsterdam, The Netherlands., Hunfeld M; Department of Pediatric Neurology, Erasmus MC Sophia Children Hospital, Rotterdam, The Netherlands., Königs M; Department of Pediatrics, Emma Neuroscience Group, Emma Children's Hospital, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2022 Jun 29; Vol. 12 (6), pp. e058975. Date of Electronic Publication: 2022 Jun 29.
DOI:	10.1136/bmjopen-2021-058975
Abstrakt:	Introduction: Traumatic brain injury (TBI) in children can be associated with poor outcome in crucial functional domains, including motor, neurocognitive and behavioural functioning. However, outcome varies between patients and is mediated by complex interplay between demographic factors, premorbid functioning and (sub)acute clinical characteristics. At present, methods to understand let alone predict outcome on the basis of these variables are lacking, which contributes to unnecessary follow-up as well as undetected impairments in children. Therefore, this study aims to develop prognostic models for the individual outcome of children with TBI in a range of important developmental domains. In addition, the potential added value of advanced neuroimaging data and the use of machine learning algorithms in the development of prognostic models will be assessed. Methods and Analysis: 210 children aged 4-18 years diagnosed with mild-to-severe TBI will be prospectively recruited from a research network of Dutch hospitals. They will be matched 2:1 to a control group of neurologically healthy children (n=105). Predictors in the model will include demographic, premorbid and clinical measures prospectively registered from the TBI hospital admission onwards as well as MRI metrics assessed at 1 month post-injury. Outcome measures of the prognostic models are (1) motor functioning, (2) intelligence, (3) behavioural functioning and (4) school performance, all assessed at 6 months post-injury. Ethics and Dissemination: Ethics has been obtained from the Medical Ethical Board of the Amsterdam UMC (location AMC). Findings of our multicentre prospective study will enable clinicians to identify TBI children at risk and aim towards a personalised prognosis. Lastly, findings will be submitted for publication in open access, international and peer-reviewed journals. Trial Registration Number: NL71283.018.19 and NL9051. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu