Placental Injury and Antibody Transfer after Coronavirus Disease 2019 in Pregnancy.

Autor:	Timi P; Emory University School of Medicine, Atlanta, Georgia, USA., Kellerhals SE; Department of Obstetrics and Gynecology, University of Arizona College of Medicine, Phoenix, Arizona, USA., Joseph NT; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Dude CM; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA., Verkerke HP; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Irby LS; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA., Smith AK; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA., Stowell SR; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Jamieson DJ; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA., Badell ML; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2023 Apr 12; Vol. 227 (7), pp. 850-854.
DOI:	10.1093/infdis/jiac270
Abstrakt:	Background: We examined the relationship between placental histopathology and transplacental antibody transfer in pregnant patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Differences in plasma concentrations of anti-receptor biding domain (RBD) immunoglobulin (Ig)G antibodies in maternal and cord blood were analyzed according to presence of placental injury. Results: Median anti-RBD IgG concentrations in cord blood with placental injury (n = 7) did not differ significantly from those without injury (n = 16) (median 2.7 [interquartile range {IQR}, 1.8-3.6] vs 2.7 [IQR, 2.4-2.9], P = 0.59). However, they were associated with lower transfer ratios (median 0.77 [IQR, 0.61-0.97] vs 0.97 [IQR, 0.80-1.01], P = 0.05). Conclusions: SARS-CoV-2 placental injury may mediate reduced maternal-fetal antibody transfer. Competing Interests: Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For cipermissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu