[Role of inflammasome NLRP3 in the pathophysiology of viral infections: A focus on SARS-CoV-2 infection].

Autor:	Chemarin M; CIRI, Centre international de recherche en infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Dufies O; Université Côte d'Azur, Inserm, C3M, Nice, France., Mazet A; CIRI, Centre international de recherche en infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Mellan E; Université Côte d'Azur, Inserm, C3M, Nice, France., Coudereau R; Laboratoire d'immunologie, Hôpital Edouard Herriot - Hospices civils de Lyon, 69437 Lyon Cedex 03, France - EA 7426 Pathophysiology of Injury-Induced Immunosuppression, Université Claude Bernard Lyon 1 - Hospices civils de Lyon - BioMérieux, Unité Mixte de Recherche HCLBioMérieux, 69003, Lyon, France., Py BF; CIRI, Centre international de recherche en infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Boyer L; Université Côte d'Azur, Inserm, C3M, Nice, France., Venet F; CIRI, Centre international de recherche en infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France - Laboratoire d'immunologie, Hôpital Edouard Herriot - Hospices civils de Lyon, 69437 Lyon Cedex 03, France.
Jazyk:	francouzština
Zdroj:	Medecine sciences : M/S [Med Sci (Paris)] 2022 Jun-Jul; Vol. 38 (6-7), pp. 545-552. Date of Electronic Publication: 2022 Jun 29.
DOI:	10.1051/medsci/2022080
Abstrakt:	NLRP3 is one of the best characterized innate immune cytosolic sensor. As part of the innate immune response, the NLRP3 inflammasome detects a wide range of danger signals such as pathogens, tissue damages, cellular stress. The priming and activation of NLRP3 lead to the formation of an oligomeric intracellular complex and to the recruitment and activation of caspase-1. Once activated, not only this inflammasome complex controls the processing and release of pro-inflammatory factors including IL-1β and IL-18, but also the inflammatory cell death pyroptosis mediated by gasdermin D pores. In this review, we describe the role of the NLRP3 inflammasome activation in viral infections with a particular interest on SARS-CoV-2 infection. In addition, we present therapies evaluated or under evaluation targeting the NLRP3 inflammasome pathway as COVID-19 treatment. (© 2022 médecine/sciences – Inserm.)
Databáze:	MEDLINE
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