Quality of Oral Anticoagulation in Atrial Fibrillation Patients at a Tertiary Hospital in Brazil.

Autor:	Malagutte KNDS; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil., Silveira CFDSMPD; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil., Reis FM; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil., Rossi DAA; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil., Hueb JC; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil., Okoshi K; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil., Nunes HRC; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil., Martin LC; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil., Bazan R; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil., Bazan SGZ; Universidade Estadual Paulista Júlio de Mesquita, Botucatu, SP - Brasil.
Jazyk:	English; Portuguese
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2022 Sep; Vol. 119 (3), pp. 363-369.
DOI:	10.36660/abc.20210805
Abstrakt:	Background: Atrial fibrillation (AF) affects 0.5% to 2.0% of the general population and is usually associated with cardiac structural diseases, hemodynamic damage, and thromboembolic complications. Oral anticoagulation prevents thromboembolic events and is monitored by the international normalized ratio (INR). Objectives: To evaluate INR stability in nonvalvular AF patients treated with warfarin anticoagulation, to evaluate thromboembolic or hemorrhagic complications, and to identify the group at higher risk for thromboembolic or hemorrhagic events. Methods: Data from the medical records of 203 patients who received medical care at a tertiary hospital in Brazil were reviewed, and the time in therapeutic range (TTR) was calculated using the Rosendaal method. The possible TTR influencing factors were then analyzed, and the relationship between the TTR and thromboembolic or hemorrhagic events was calculated. The level of significance was 5%. Results: The mean TTR was 52.2%. Patients with INR instability in the adaptation phase had a lower mean TTR (46.8%) than those without instability (53.9%). Among the studied patients, 6.9% suffered hemorrhagic events, and 8.4% had a stroke. The higher risk group for stroke and bleeding consisted of patients with INR instability in the adaptation phase. Conclusions: The quality of anticoagulation in this tertiary hospital in Brazil is similar to that in centers in developing countries. Patients with greater INR instability in the adaptation phase evolved to a lower mean TTR during follow-up, had a 4.94-fold greater chance of stroke, and had a 3.35-fold greater chance of bleeding. Thus, for this patient group, individualizing the choice of anticoagulation therapy would be advised, considering the cost-benefit ratio.
Databáze:	MEDLINE
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