EFFECT OF HYPERBARIC OXYGEN THERAPY ON NERVE REGENERATION IN RATS.

Autor:	Barros TFDS; Universidade de São Paulo, Medical School, Hospital das Clínicas, Institute of Orthopedics and Traumatology, Hand Surgery and Reconstructive Microsurgery Group, São Paulo, SP, Brazil., Paulos RG; Universidade de São Paulo, Medical School, Hospital das Clínicas, Institute of Orthopedics and Traumatology, Hand Surgery and Reconstructive Microsurgery Group, São Paulo, SP, Brazil., Iwase FDC; Universidade de São Paulo, Medical School, Hospital das Clínicas, Institute of Orthopedics and Traumatology, Hand Surgery and Reconstructive Microsurgery Group, São Paulo, SP, Brazil., Santos GBD; Universidade de São Paulo, Medical School, Hospital das Clínicas, Institute of Orthopedics and Traumatology, Hand Surgery and Reconstructive Microsurgery Group, São Paulo, SP, Brazil., Rezende MR; Universidade de São Paulo, Medical School, Hospital das Clínicas, Institute of Orthopedics and Traumatology, Hand Surgery and Reconstructive Microsurgery Group, São Paulo, SP, Brazil., Mattar R; Universidade de São Paulo, Medical School, Hospital das Clínicas, Institute of Orthopedics and Traumatology, Hand Surgery and Reconstructive Microsurgery Group, São Paulo, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Acta ortopedica brasileira [Acta Ortop Bras] 2022 Apr 15; Vol. 30 (2), pp. e191015. Date of Electronic Publication: 2022 Apr 15 (Print Publication: 2022).
DOI:	10.1590/1413-785220223002191015
Abstrakt:	Objective: To evaluate histological changes in peripheral nerves of rats after sciatic nerve neurorrhaphy, according to the time of exposure to hyperbaric oxygen chamber treatment. Methods: Twenty-five Wistar rats were divided into 5 groups according to the amount of exposure to hyperbaric oxygen chamber treatment. Group 1 was the control and there was no use of hyperbaric oxygen chamber; group 2 received one week of therapy; group 3, two weeks; group 4, three weeks; and group 5, four weeks. After the fourth postoperative week, the animals were submitted to euthanasia and a sciatic nerve sample sent for histological analysis. Axons proximal and distal to the neurorrhaphy were counted with axonal regeneration index measurement. Results: We observed that the number of axons distal to neurorrhaphy increases with the amount of hyperbaric oxygen chamber exposure, the results were more expressive from the third week of treatment. However, the statistical analysis found no significant difference between the groups. Conclusion: The descriptive analysis suggests benefit of using hyperbaric oxygen chamber directly proportional to the time of therapy. The study, however, did not present statistically relevant results, probably due to the reduced sample size. Subsequent studies with more significant sampling would be of great value. Level of Evidence II, Prospective Comparative Study. Competing Interests: All authors declare no potential conflict of interest related to this article.
Databáze:	MEDLINE
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