Arterial Anastomosis Using Microsurgical Techniques in Adult Live Donor Liver Transplant: A Focus on Technique and Outcomes at a Single Institution.
| Autor: | Huang S; Keck School of Medicine, University of Southern California, Los Angeles, California., Fahradyan A; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Southern California, Los Angeles, California., Ahearn A; Division of Hepatobiliary and Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California., Kaur N; Division of Hepatobiliary and Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California., Sher L; Division of Hepatobiliary and Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California., Genyk Y; Division of Hepatobiliary and Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California., Emamaullee J; Division of Hepatobiliary and Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California., Patel K; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Southern California, Los Angeles, California., Carey JN; Keck School of Medicine, University of Southern California, Los Angeles, California.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Southern California, Los Angeles, California. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of reconstructive microsurgery [J Reconstr Microsurg] 2023 Jan; Vol. 39 (1), pp. 70-80. Date of Electronic Publication: 2022 Jun 28. |
| DOI: | 10.1055/s-0042-1749339 |
| Abstrakt: | Background: Microvascular hepatic artery reconstruction (MHAR) is associated with decreased rates of hepatic artery thrombosis (HAT) in living donor liver transplantation (LDLT). There is a paucity of literature describing the learning points and initiation of this technique at the institutional level. The objective of this study is to report our institutional experience using MHAR in adult LDLT with a focus on technique and outcomes. Methods: A retrospective review of adult patients who underwent LDLT from January 2012 to December 2020 was conducted. Patients were divided into two groups, those who underwent LDLT without MHAR and with MHAR. We analyzed cases for technical data including donor and recipient artery characteristics, anastomotic techniques, intraop events, and postop complications. A Mann-Whitney test was performed to compare outcomes between non-MHAR and MHAR patients. Results: Fifty non-MHAR and 50 MHAR patients met inclusion criteria. Median age at transplantation was 58 (interquartile range [IQR] 11.8) and 57.5 years (IQR 14.5), respectively. Median follow-up for MHAR patients was 12.8 months (IQR 11.6). The most common recipient arteries were the right hepatic artery (HA) (58%) and left HA (20%). Median size of recipient and donor arteries were 3.3 mm (IQR 0.7) and 3.1 mm (IQR 0.7), resulting in a median mismatch size of 0.3 mm (IQR 0.4). Median microanastomosis time was 44 minutes (IQR 0). HAT, graft failure, and mortality rates were higher in the non-MHAR cohort (6% vs. 0%, 8% vs. 0%, and 16% vs. 6%, respectively); however, these did not reach statistical significance. Conclusion: This study found lower rates of HAT and graft failure after implementing MHAR, though statistical significance was not achieved. Larger cohort studies are needed to further assess the potential benefit of MHAR in adult LDLT. From our experience, MHAR requires cooperation between the transplant and microsurgical teams, with technical challenges overcome with appropriate instrumentation and planning. Competing Interests: None declared. (Thieme. All rights reserved.) |
| Databáze: | MEDLINE |
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