High-density EEG sleep correlates of cognitive and affective impairment at 12-month follow-up after COVID-19.

Autor: Rubega M; Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy. Electronic address: maria.rubega@unipd.it., Ciringione L; Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy. Electronic address: luciana.ciringione@unipd.it., Bertuccelli M; Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: margherita.bertuccelli@phd.unipd.it., Paramento M; Department of Information Engineering, University of Padova, via Gradenigo 6/B, Padova 35131, Italy. Electronic address: matilde.paramento@studenti.unipd.it., Sparacino G; Department of Information Engineering, University of Padova, via Gradenigo 6/B, Padova 35131, Italy. Electronic address: gianni@dei.unipd.it., Vianello A; Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova, via Giustiniani, 2, Padova 35128, Italy. Electronic address: andrea.vianello.1@unipd.it., Masiero S; Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: stef.masiero@unipd.it., Vallesi A; Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: antonino.vallesi@unipd.it., Formaggio E; Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: emanuela.formaggio@unipd.it., Del Felice A; Department of Neuroscience, Section of Rehabilitation, University of Padova, via Giustiniani, 3, Padova 35128, Italy; Padova Neuroscience Center, University of Padova, via Orus 2/B, Padova 35129, Italy. Electronic address: alessandra.delfelice@unipd.it.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2022 Aug; Vol. 140, pp. 126-135. Date of Electronic Publication: 2022 Jun 15.
DOI: 10.1016/j.clinph.2022.05.017
Abstrakt: Objective: To disentangle the pathophysiology of cognitive/affective impairment in Coronavirus Disease-2019 (COVID-19), we studied long-term cognitive and affective sequelae and sleep high-density electroencephalography (EEG) at 12-month follow-up in people with a previous hospital admission for acute COVID-19.
Methods: People discharged from an intensive care unit (ICU) and a sub-intensive ward (nonICU) between March and May 2020 were contacted between March and June 2021. Participants underwent cognitive, psychological, and sleep assessment. High-density EEG recording was acquired during a nap. Slow and fast spindles density/amplitude/frequency and source reconstruction in brain gray matter were extracted. The relationship between psychological and cognitive findings was explored with Pearson correlation.
Results: We enrolled 33 participants ( 17 nonICU) and 12 controls. We observed a lower Physical Quality of Life index, higher post-traumatic stress disorder (PTSD) score, and a worse executive function performance in nonICU participants. Higher PTSD and Beck Depression Inventory scores correlated with lower executive performance. The same group showed a reorganization of spindle cortical generators.
Conclusions: Our results show executive and psycho-affective deficits and spindle alterations in COVID-19 survivors - especially in nonICU participants - after 12 months from discharge.
Significance: These findings may be suggestive of a crucial contribution of stress experienced during hospital admission on long-term cognitive functioning.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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