Anti-SARS-CoV-2 IgG antibodies pre- and post-vaccination behavior in health workers from a Guatemalan cancer center.

Autor:	Carías-Alvarado CC; Cancer Biological Research Laboratory, Liga Nacional Contra el Cáncer-Instituto de Cancerología, Guatemala, Guatemala., López-Hun F; Cancer Biological Research Laboratory, Liga Nacional Contra el Cáncer-Instituto de Cancerología, Guatemala, Guatemala., Valvert F; Cancer Biological Research Laboratory, Liga Nacional Contra el Cáncer-Instituto de Cancerología, Guatemala, Guatemala., Barrios-Menéndez JC; Cancer Biological Research Laboratory, Liga Nacional Contra el Cáncer-Instituto de Cancerología, Guatemala, Guatemala., Kihn-Alarcón A; Department of Research, Liga Nacional Contra el Cáncer-Instituto de Cancerología, Guatemala, Guatemala., Falla V; Department of Research, Liga Nacional Contra el Cáncer-Instituto de Cancerología, Guatemala, Guatemala., Xu X; Cancer Center, Renmin Hospital, Wuhan University, Wuhan, China., Escobar-Castro K; Clinical Laboratory, Liga Nacional Contra el Cáncer-Instituto de Cancerología, Guatemala, Guatemala.
Jazyk:	angličtina
Zdroj:	Gaceta medica de Mexico [Gac Med Mex] 2022; Vol. 158 (2), pp. 78-82.
DOI:	10.24875/GMM.M22000645
Abstrakt:	Introduction: The study of anti-SARS-CoV-2 IgG antibodies allows asymptomatic individuals with COVID-19 to be identified, and post-infection and post-vaccination immunity status to be evaluated. Objective: To know the behavior of anti-SARS-CoV-2 IgG antibodies before and after vaccination in workers of a cancer center. Methods: Prior to the application of the vaccine, the presence of anti-SARS-CoV-2 IgG antibodies (n = 171) was analyzed by evaluating anti-N IgG antibodies; post-vaccination, after receiving the second dose, anti-S IgG antibodies were evaluated (n = 60). Results: Prior to vaccination, IgG antibodies were present in 18.71% of participants; they were detected in 65.22% of those with prior history of COVID-19 diagnosis and in 11.49% of those without it. The positions with the highest prevalence were nurses (28.26%), paramedics (27.59%) and administrative workers (27.78%), p < 0.01. Anosmia, ageusia and chest tightness were associated with the presence of IgG (p < 0.05). Post-vaccination, all participants developed IgG antibodies; people with a previous COVID-19 diagnosis had higher titers: 10,277 vs. 6,819 AU/mL, p < 0.001. Conclusions: The study of anti-SARS-CoV-2 IgG antibodies allowed asymptomatic health workers to be identified. A high percentage of participants with prior COVID-19 diagnosis had antibodies. All participants developed IgG antibodies after vaccination, with higher titers being identified in those with previous infection. (Copyright: © 2022 Permanyer.)
Databáze:	MEDLINE
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