| Autor: |
Maltseva ES; Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova Street 9, Saint Petersburg 191002, Russia., Nikolaeva VO; Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova Street 9, Saint Petersburg 191002, Russia., Savin AM; Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova Street 9, Saint Petersburg 191002, Russia., Dobryakov MY; Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova Street 9, Saint Petersburg 191002, Russia., Koshel EI; Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova Street 9, Saint Petersburg 191002, Russia., Krivoshapkin PV; Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova Street 9, Saint Petersburg 191002, Russia., Krivoshapkina EF; Institute of Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova Street 9, Saint Petersburg 191002, Russia. |
| Abstrakt: |
Since the outcome of an operation largely depends on the quality of wound healing, it is one of the most challenging stages in surgery. Today, wound closure is mostly undertaken by means of a surgical suture. Good surgical sutures are biocompatible and biodegradable and possess excellent mechanical properties. Preferably, these sutures demonstrate optical activity for bacteria detection as there is a risk of surgical site infections. In this study, a solution, which fulfills all the requirements for manufacturing a multifunctional hybrid material, is proposed. In this work, a method for the in situ modification of spider silk with fluorescent carbon dots has been developed. The basic concept is the use of silk fibers as both the main framework for tissue regeneration and a carbon source during carbon dot synthesis. The resulting hybrid material exhibits strong photoluminescence in the red region of the spectrum (590 nm) when irradiated with blue light (480 nm). The proposed approach potentially allows for simultaneous wound closure and pathogen detection. |
