Beneficial effects of Salvia officinalis essential oil on vanadium-induced testicular injury, DNA damage and histological alterations in Wistar rats.

Autor: Ghorbel Koubaa F; Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia. fatmaghorbelkoubaa@yahoo.fr., Chaâbane M; Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia., Chiab N; Laboratory of Plant Improvement and Agri-Resources Valorization, National School of Engineers of Sfax (ENIS), Sfax, Tunisia., Jdidi H; Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia., Sefi M; Physiology and Aquatic Environment Unit, Department of Biological Sciences, University of Tunis El Manar, Tunis, Tunisia., Boudawara O; Laboratory of Histopathology Laboratory, Faculty of Medicine, University of Sfax, Sfax, Tunisia., Turki M; Laboratory of Biochemistry, Faculty of Medicine, University of Sfax, 3029, Sfax, Tunisia., Gargouri Bouzid R; Laboratory of Plant Improvement and Agri-Resources Valorization, National School of Engineers of Sfax (ENIS), Sfax, Tunisia., Boudawara Sellami T; Laboratory of Histopathology Laboratory, Faculty of Medicine, University of Sfax, Sfax, Tunisia., Makni Ayadi F; Laboratory of Biochemistry, Faculty of Medicine, University of Sfax, 3029, Sfax, Tunisia., El Feki A; Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia.
Jazyk: angličtina
Zdroj: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2022 Oct; Vol. 35 (5), pp. 833-851. Date of Electronic Publication: 2022 Jun 28.
DOI: 10.1007/s10534-022-00407-3
Abstrakt: Vanadium has been shown to catalyze the generation of reactive oxygen species. Since free radical production and lipid peroxidation are potentially important mediators in testicular physiology and pathophysiology, the present study was conducted to elucidate vanadium-induced oxidative damage in rat testis and the ameliorative role of Salvia officinalis essential oil (SEO) against the adverse effects of this heavy metal. Adult male Wistar rats were treated daily during 10 days either with ammonium metavanadate (5 mg/kg bw, intraperitoneally), SEO (15 mg/kg bw, orally) or their combination. A group of rats receiving daily a saline solution served as a negative control. Vanadium treatment induced a significant decrease in body and reproductive organ weights, serum testosterone level and sperm number and motility. An increase in lipid peroxidation and protein oxidation as well as a marked inhibition in the activities of antioxidant enzymes in the testes and seminal vesicles indicated the occurrence of oxidative stress after vanadium toxicity. Histopathological changes in testis and seminal vesicles were also observed following vanadium administration. However, co-administration of SEO to vanadium-treated rats resulted in an appreciable improvement of these parameters, emphasizing the therapeutic effects of SEO. It can be suggested that SEO mitigates vanadium-induced reproductive damage due to its antioxidant capacity. Thus, we can hypothesize that SEO supplementation could protect against vanadium poisoning.
(© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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