Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study.

Autor:	Attauabi M; Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark.; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark., Madsen GR; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark.; Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark., Bendtsen F; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark.; Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark., Wewer AV; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark.; The Paediatric Department, Hvidovre Hospital, Hvidovre, Denmark., Wilkens R; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark.; Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark., Ilvemark J; Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark., Vladimirova N; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark., Jensen AB; Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark., Jensen FK; Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark., Hansen SB; Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark., Siebner HR; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark.; Department of Neurology, Bispebjerg Hospital, Kobenhavn, Denmark., Nielsen YJW; Department of Radiology, Herlev Hospital, Herlev, Denmark., Møller JM; Department of Radiology, Herlev Hospital, Herlev, Denmark., Thomsen HS; Department of Radiology, Herlev Hospital, Herlev, Denmark., Thomsen SF; Department of Dermatology, Bispebjerg Hospital, Kobenhavn, Denmark., Ingels HAS; Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Kobenhavn, Denmark., Theede K; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark.; Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark., Boysen T; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark.; Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark., Bjerrum JT; Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark., Jakobsen C; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark.; The Paediatric Department, Hvidovre Hospital, Hvidovre, Denmark., Dorn-Rasmussen M; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark.; The Paediatric Department, Hvidovre Hospital, Hvidovre, Denmark., Jansson S; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark.; The Paediatric Department, Hvidovre Hospital, Hvidovre, Denmark., Yao Y; Department of Dermatology, Bispebjerg Hospital, Kobenhavn, Denmark., Burian EA; Department of Dermatology, Bispebjerg Hospital, Kobenhavn, Denmark., Møller FT; Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Kobenhavn, Denmark., Fana V; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, Denmark., Wiell C; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, Denmark., Terslev L; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Glostrup, Denmark., Østergaard M; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, Denmark., Bertl K; Department of Periodontology, Malmö Universitet, Malmo, Sweden., Stavropoulos A; Malmo Universitet, Malmo, Sweden.; Division of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria., Seidelin JB; Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark., Burisch J; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark johan.burisch@regionh.dk.; Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2022 Jun 27; Vol. 12 (6), pp. e055779. Date of Electronic Publication: 2022 Jun 27.
DOI:	10.1136/bmjopen-2021-055779
Abstrakt:	Introduction: Inflammatory bowel diseases (IBD), encompassing Crohn's disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogeneous course of IBD, including need for, and response to, treatment. Methods and Analysis: IBD Prognosis Study is a prospective, population-based inception cohort study of unselected, newly diagnosed adult, adolescent and paediatric patients with IBD within the uptake area of Hvidovre University Hospital and Herlev University Hospital, Denmark, which covers approximately 1 050 000 inhabitants (~20% of the Danish population). The diagnosis of IBD will be according to the Porto diagnostic criteria in paediatric and adolescent patients or the Copenhagen diagnostic criteria in adult patients. All patients will be followed prospectively with regular clinical examinations including ileocolonoscopies, MRI of the small intestine, validated patient-reported measures and objective examinations with intestinal ultrasound. In addition, intestinal biopsies from ileocolonoscopies, stool, rectal swabs, saliva samples, swabs of the oral cavity and blood samples will be collected systematically for the analysis of biomarkers, microbiome and genetic profiles. Environmental factors and quality of life will be assessed using questionnaires and, when available, automatic registration of purchase data. The occurrence and course of extraintestinal manifestations will be evaluated by rheumatologists, dermatologists and dentists, and assessed by MR cholangiopancreatography, MR of the spine and sacroiliac joints, ultrasonography of peripheral joints and entheses, clinical oral examination, as well as panoramic radiograph of the jaws. Fibroscans and dual-energy X-ray absorptiometry scans will be performed to monitor occurrence and course of chronic liver diseases, osteopenia and osteoporosis. Ethics and Dissemination: This study has been approved by Ethics Committee of the Capital Region of Denmark (approval number: H-20065831). Study results will be disseminated through publication in international scientific journals and presentation at (inter)national conferences. Competing Interests: Competing interests: HRS: HRS has received honoraria as speaker from Sanofi Genzyme, Denmark and Novartis, Denmark, as consultant from Sanofi Genzyme, Denmark, Lophora, Denmark, and Lundbeck AS, Denmark, and as editor-in-chief (Neuroimage Clinical) and senior editor (NeuroImage) from Elsevier Publishers, Amsterdam, The Netherlands. He has received royalties as book editor from Springer Publishers, Stuttgart, Germany and from Gyldendal Publishers, Copenhagen, Denmark. JBS: Has received unrestricted research grants from Janssen and Takeda and is national coordinator of clinical trials from Boerhinger Ingelheim and Eli Lilly. JB: Personal fees from AbbVie, Janssen-Cilag, Celgene, Samsung Bioepis, and Pfizer; grants and personal fees from Takeda, MSD, and Tillots Pharma; grants from Novo Nordisk Foundation and Bristol Meyers Squibb. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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