Gastrointestinal Myoelectric Measurements via Simultaneous External and Internal Electrodes in Pigs.

Autor: Salimi-Jazi F; Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California., Thomas AL; Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California., Rafeeqi T; Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California., Diyaolu M; Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California., Wood LSY; Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California., Axelrod S; G-Tech Medical, Fogarty Innovation, Mountain View, California., Navalgund A; G-Tech Medical, Fogarty Innovation, Mountain View, California., Axelrod L; G-Tech Medical, Fogarty Innovation, Mountain View, California., Dunn JCY; Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California; Department of Bioengineering, Stanford University, Stanford, California. Electronic address: jdunn2@stanford.edu.
Jazyk: angličtina
Zdroj: The Journal of surgical research [J Surg Res] 2022 Nov; Vol. 279, pp. 119-126. Date of Electronic Publication: 2022 Jun 24.
DOI: 10.1016/j.jss.2022.05.012
Abstrakt: Introduction: Currently, there is no accurate noninvasive measurement system to diagnose gastrointestinal (GI) motility disorders. Wireless skin patches have been introduced to provide an accurate noninvasive measurement of GI myoelectric activity which is essential for developing neuro-stimulation devices to treat GI motility disorders. The aim of this study is to compare the external and internal electrical signal measurements in ambulatory pigs.
Methods: Yucatan pigs underwent placement of internal electrodes on the stomach, small intestine, and colon. Wires were brought through the abdominal wall. Signals were collected by a wireless receptor. Four external patches were placed on the abdominal skin to record the signals simultaneously. Pigs were kept for 6 d while the sensors were continuously recording the data from both systems.
Results: Internal sensors detected rich signals from each organ. The stomach had a dominant frequency that ranged from 4 to 4.5 cpm, with occasional higher frequencies at 2, 3 and 4 times that. Small intestine signals had their primary energy in the 12-15 cpm range. Colon signals primarily displayed a dominant broad peak in the 4-6 cpm region. External skin patches detected a substantial fraction of the activities measured by the internal electrodes. A clear congruence in the frequency spectrum was observed between the internal and external readings.
Conclusions: Internally measured myoelectrical signals confirmed different patterns of rhythmic activity of the stomach, small intestine, and colon. Skin patches provided GI myoelectric measurement with a range of frequencies that could be useful in the diagnosis and treatment of motility disorders.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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