THE PROGNOSTIC UTILITY OF LEUKOCYTE AND PLATELET COUNTS FOR RISK ASSESSMENT OF IN-HOSPITAL COMPLICATIONS IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION.

Autor:	Shumakov OV; NATIONAL SCIENTIFIC CENTER «INSTITUTE OF CARDIOLOGY NAMED AFTER ACAD. M.D. STRAZHESKA» NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE., Dovhan ОV; NATIONAL SCIENTIFIC CENTER «INSTITUTE OF CARDIOLOGY NAMED AFTER ACAD. M.D. STRAZHESKA» NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE., Talaeva TV; NATIONAL SCIENTIFIC CENTER «INSTITUTE OF CARDIOLOGY NAMED AFTER ACAD. M.D. STRAZHESKA» NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE., Тretiak IV; NATIONAL SCIENTIFIC CENTER «INSTITUTE OF CARDIOLOGY NAMED AFTER ACAD. M.D. STRAZHESKA» NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE., Parkhomenko ОМ; NATIONAL SCIENTIFIC CENTER «INSTITUTE OF CARDIOLOGY NAMED AFTER ACAD. M.D. STRAZHESKA» NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE., Gurjeva OS; NATIONAL SCIENTIFIC CENTER «INSTITUTE OF CARDIOLOGY NAMED AFTER ACAD. M.D. STRAZHESKA» NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE.
Jazyk:	angličtina
Zdroj:	Wiadomosci lekarskie (Warsaw, Poland : 1960) [Wiad Lek] 2022; Vol. 75 (5 pt 2), pp. 1317-1322.
DOI:	10.36740/WLek202205216
Abstrakt:	Objective: The aim: We have aimed to develop method of risk assessment in patients with acute STEMI using blood cells count useful in everyday clinical practice. Patients and Methods: Materials and methods: 317 STEMI patients admitted to ICCU starting at 01/2014 to 06/2020 were included in this study. Data were evaluated partially retrospectively (n=214), 1st group) and prospectively, applying new risk-assessment tool in 103 patients 2nd group). Study groups did not differ in terms of all clinical characteristics. Results: Results: To evaluate criteria of severity of in-hospital complication we have created in-hospital complication index (HCI), composed according to number of adverse events per patient. Based on correlation analyses we have composed complex WBC-platelets (WBC-PLT) index = ((GRA - MON) / LYM) · 10 + PDWc + P-LCR). In the 1st study group WBC-PLT index was associated with in-hospital complications' index and correlated with neutrophil-leukocytes ratio (NLR) (p<0,001 and p<0,0005 respectively). WBC-PLT index > 137 appeared to be mildly associated with increased risk of adverse in-hospital outcomes (with specificity of 78 % and low sensitivity of 64 %, AUC- 0,72). Further prospective study of WBC-PLT index measured on the first STEMI-day (group 2) revealed that this parameter was more informative regarding association with adverse in-hospital events whereas NLR had low accuracy in risk assessment. Conclusion: Conclusions: WBC-PLT index assessed on the first STEMI day may be used as a tool for detection of patients at risk of adverse in-hospital events in the every-day clinical practice.
Databáze:	MEDLINE
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