Recurrent spinal cord compression due to extramedullary hematopoiesis in thalassemia patient: Case report.

Autor:	Abbarh S; Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar., Al-Mashdali AF; Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar., Abdelrazek M; Radiology Department, Hamad Medical Corporation, Doha, Qatar., Gurusamy VM; Radiation Oncology Department, Hamad Medical Corporation, Doha, Qatar., Yassin MA; Hematology and Oncology Department, Hamad Medical Corporation, Doha, Qatar.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2022 Jun 24; Vol. 101 (25), pp. e29334. Date of Electronic Publication: 2022 Jun 24.
DOI:	10.1097/MD.0000000000029334
Abstrakt:	Introduction: Spinal cord compression secondary to extramedullary hematopoiesis (EMH) is a rare condition. Variable treatment options have been reported with different efficacy and recurrence rate. Due to its rarity, no clear optimal management guidelines have been established yet. Patient Concerns and Diagnosis: We report a recurrence of spinal cord compression secondary to EMH in a 19-year-old male, with a background of transfusion-dependent beta-thalassemia on luspatercept, who presented with weakness in both lower limbs. Interventions and Outcomes: He was treated successfully both times with radiotherapy. Conclusion: Early diagnosis and management of EMH compressing the spinal cord are essential to prevent permanent neurological damage. Diagnosis should be suspected based on the clinical presentation and magnetic resonance imaging findings in a patient with a history of ineffective hemopoiesis. Treatment option remains controversial. Radiotherapy option seems effective, even in recurrent cases, and valid, particularly for those at high risk of surgery or who do not prefer it. Competing Interests: The authors have no conflicts of interests to disclose. (Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu