Sports activities at a young age decrease hypertension risk-The J-Fit + study.

Autor: Kumagai H; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.; The Leonard Davis School of Gerontology, University of Southern California, California, Los Angeles, California, USA., Miyamoto-Mikami E; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Someya Y; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Kidokoro T; Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan., Miller B; The Leonard Davis School of Gerontology, University of Southern California, California, Los Angeles, California, USA., Kumagai ME; The Leonard Davis School of Gerontology, University of Southern California, California, Los Angeles, California, USA.; Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, California, USA., Yoshioka M; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.; Japan Society for the Promotion of Science, Tokyo, Japan., Choi Y; Institute of Sports & Arts Convergence, Inha University, Incheon, South Korea., Tagawa K; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan., Maeda S; Faculty of Sport Sciences, Waseda University, Saitama, Japan., Kohmura Y; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Suzuki K; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Machida S; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Naito H; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Fuku N; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2022 Jun; Vol. 10 (12), pp. e15364.
DOI: 10.14814/phy2.15364
Abstrakt: This study aimed to assess (1) blood pressure between young, current athletes, and non-athletes early in life; (2) hypertension prevalence between former athletes and the general population later in life; and (3) understand the mechanisms between exercise training and hypertension risks in the form of DNA methylation. Study 1: A total of 354 young male participants, including current athletes, underwent blood pressure assessment. Study 2: The prevalence of hypertension in 1269 male former athletes was compared with that in the Japanese general population. Current and former athletes were divided into three groups: endurance-, mixed-, and sprint/power-group. Study 3: We analyzed the effect of aerobic- or resistance-training on DNA methylation patterns using publicly available datasets to explore the possible underlying mechanisms. In young, current athletes, the mixed- and sprint/power-group exhibited higher systolic blood pressure, and all groups exhibited higher pulse pressure than non-athletes. In contrast, the prevalence of hypertension in former athletes was significantly lower in all groups than in the general population. Compared to endurance-group (reference), adjusted-hazard ratios for the incidence of hypertension among mixed- and sprint/power-group were 1.24 (0.87-1.84) and 1.50 (1.04-2.23), respectively. Moreover, aerobic- and resistance-training commonly modified over 3000 DNA methylation sites in skeletal muscle, and these were suggested to be associated with cardiovascular function-related pathways. These findings suggest that the high blood pressure induced by exercise training at a young age does not influence the development of future hypertension. Furthermore, previous exercise training experiences at a young age could decrease the risk of future hypertension.
(© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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