Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents.

Autor:	Alqaderi H; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.; Kuwait School Oral Health Program, Ministry of Health, Kuwait City, Kuwait.; Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, United States., Hegazi F; Department of Preventive Dental Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Al-Mulla F; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait., Chiu CJ; Center for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United States., Kantarci A; Center for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United States., Al-Ozairi E; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.; Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait., Abu-Farha M; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait., Bin-Hasan S; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait.; Farwaniya Hospital, Ministry of Health, Sabah Al Nasser, Kuwait., Alsumait A; Kuwait School Oral Health Program, Ministry of Health, Kuwait City, Kuwait., Abubaker J; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait., Devarajan S; Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, Kuwait., Goodson JM; Center for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United States., Hasturk H; Center for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United States., Tavares M; Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, United States.; Center for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United States.; Department of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2022 Jun 10; Vol. 10, pp. 800373. Date of Electronic Publication: 2022 Jun 10 (Print Publication: 2022).
DOI:	10.3389/fpubh.2022.800373
Abstrakt:	Introduction: Childhood obesity presents a major risk for metabolic diseases in adulthood. Noninvasive methods are needed for predicting the course of obesity in children and its complications. Using blood for longitudinal analyses of biomarkers to predict disease in children is not a convenient method. Saliva presents a noninvasive platform to detect inflammatory changes in biomarkers as possible predictive measures of future pathological events. Objectives: The aim of this study was to evaluate the relationship between specific salivary biomarkers, obesity, and intermediate hyperglycemia in children. We also investigated the longitudinal association between the salivary biomarkers and change in Body Mass Index-for-age percentile scores (BMIz). Methods: Data on 353 adolescents were collected from the individuals recruited for seven years in an ongoing Kuwait Healthy Life Study cohort. BMIz was measured at 10, 12, and 17 years of age. Interleukin (IL)-6, IL-8, IL-10, Leptin, C-Reactive Protein (CRP), Insulin, Vascular Endothelial Growth Factor (VEGF), and Monocyte Chemoattractant Protein-1 (MCP-1) were measured in saliva and serum. Additionally, fasting blood plasma glucose levels were recorded. Multilevel longitudinal regression modeling, mediation analyses, and logistic regression were used to determine the predictive value of salivary biomarkers in obesity and hyperglycemia. Results: Longitudinal analyses showed that with each one-unit increase of salivary CRP and insulin, there was a 3.5 kg/m 2 and 3.2 kg/m 2 increase in BMIz, respectively. Comparable to serum CRP and insulin, higher salivary CRP and insulin OR 4.94 [95%CI: 1.66,14., OR 2.64 [95%CI: 1.09, 6.38], respectively) were predictive of hyperglycemia and obesity (OR 4.53 [95%CI: 2.40,8.50], OR 3.29 [95%CI: 1.82,5.97], respectively). Insulin was a strong mediator in the relationship between obesity and hyperglycemia. Conclusion: Our findings demonstrated that salivary CRP and insulin were associated with hyperglycemia, obesity, and possibly diabetes in adolescents. Salivary biomarkers are a noninvasive approach with significant value for disease risk assessment and prevention. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Alqaderi, Hegazi, Al-Mulla, Chiu, Kantarci, Al-Ozairi, Abu-Farha, Bin-Hasan, Alsumait, Abubaker, Devarajan, Goodson, Hasturk and Tavares.)
Databáze:	MEDLINE
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