Effect of intensive weekend mindfulness-based intervention on BDNF, mitochondria function, and anxiety. A randomized, crossover clinical trial.

Autor:	Gomutbutra P; Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Thailand.; The Northern Neuroscience Center, Faculty of Medicine, Chiang Mai University, Thailand., Srikamjak T; Department of Occupational Therapy, Faculty of Associated Medicine, Chiang Mai University, Thailand., Sapinun L; The Nursing Service Division, Maharaj Nakorn Chiang Mai Hospital, Thailand., Kunaphanh S; The Nursing Service Division, Maharaj Nakorn Chiang Mai Hospital, Thailand., Yingchankul N; Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Thailand., Apaijai N; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand.; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Thailand.; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Thailand., Shinlapawittayatorn K; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand.; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Thailand.; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Thailand., Phuackchantuck R; Research Administration Section, Faculty of Medicine, Chiang Mai University Chiang Mai, Thailand., Chattipakorn N; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand.; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Thailand.; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Thailand., Chattipakorn S; Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand.; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Thailand.
Jazyk:	angličtina
Zdroj:	Comprehensive psychoneuroendocrinology [Compr Psychoneuroendocrinol] 2022 Apr 29; Vol. 11, pp. 100137. Date of Electronic Publication: 2022 Apr 29 (Print Publication: 2022).
DOI:	10.1016/j.cpnec.2022.100137
Abstrakt:	Background: The previous metanalysis found that Mind-body intervention (MBI) improves neuropsychologic well-being and may increase brain-derived growth factor (BDNF). BDNF is a neurotrophic factor related to neuroplasticity. Objective: To evaluate the effect of the short intensive MBI compared to control-relaxation on Site on BDNF and examine if this change is related to mitochondria function or stress-related neurohormonal activity. Methods: Randomized, controlled, two-period cross-over trial conducted in a medical center in Thailand. Healthy-meditation naive Nurse and Occupational Therapy Students, 23 assigned randomly to MBI, and 24 relaxations at the site for 8 h during the weekend. The wash-out period was three months between the two periods. All volunteers took the blood test for BDNF, mitochondrial oxidative phosphorylation (OXPHOS), Cortisol, and Heart rate variability (HRV) measurement before and Visual Analogue Scale for Anxiety (VAS-A), forward and backward digit span after each period. Results: A total of 40 participants finished the trials. The cross over trial analysis showed a significant treatment effect between MBI and Relaxation on-site for the mean VAS-A as 9.89 (95% CI 4.81 to 19.47; P = 0.001), serum BDNF as 1.24 (95% CI 0.16 to 2.32; P = 0.04), and OXPHOS complex-1 was decreased 0.41 (95% CI 0.03-0.29 p = 0.03). There were no significant differences for digit span, cortisol, and HRV. Conclusion: In healthy meditation naïve females, even a short period of MBI may increase serum BDNF and reduce anxiety more than relaxation on-site. The more reduction of OXPHOS complex-1 in the mindfulness group suggests oxidative stress may be a more sensitive indicator than stress-related neurohormonal activity. Competing Interests: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. (© 2022 The Author(s).)
Databáze:	MEDLINE
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