Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeys.

Autor: Piantella S; Department of Psychology and Counselling, La Trobe University, Melbourne, VIC, Australia., O'Brien WT; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia., Hale MW; Department of Psychology and Counselling, La Trobe University, Melbourne, VIC, Australia., Maruff P; The Florey Institute, The University of Melbourne, Melbourne, VIC, Australia., McDonald SJ; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia., Wright BJ; Department of Psychology and Counselling, La Trobe University, Melbourne, VIC, Australia.
Jazyk: angličtina
Zdroj: Comprehensive psychoneuroendocrinology [Compr Psychoneuroendocrinol] 2022 Apr 01; Vol. 10, pp. 100131. Date of Electronic Publication: 2022 Apr 01 (Print Publication: 2022).
DOI: 10.1016/j.cpnec.2022.100131
Abstrakt: Jockeys work in high-risk environments that rely heavily on attention- and decision-making to perform well and safely. Workplace stress literature has often overlooked the impact of stress on cognition, and designs that include physiological measures are rare. This study assessed the prospective concurrent relationships between workplace stress, depression symptoms and low-grade inflammation with cognitive performance among professional jockeys. Professional jockeys ( N  = 35, M age  = 32.29) provided information on workplace stress and depression symptoms, with serum levels of inflammatory cytokines (IL-6, IL-10, TNFα) and cytokine balance (IL-6: IL-10, TNFα: IL-10) quantified with SIMOA, and cognitive performance with CogSport computer-based testing battery. These measures were repeated after a twelve-month interval. Increased workplace stress between testing intervals was associated to an increased cytokine imbalance (β = 0.447, p = .015) after controlling for age and gender. Increases in cytokine imbalance occurred in unison with decreases in attention (β = 0.516, p = .002), decision-making (β = 0.452, p = .009) and working memory (β = 0.492, p = .004). These preliminary findings suggest the underlying mechanisms linking workplace stress and reduced cognitive performance may be influenced by measures of low-grade inflammation and specifically a cytokine imbalance. Our findings suggest a measure of cytokine balance may explain the heterogenous findings in previous studies that have focussed solely on the association of workplace stress with pro-inflammatory cytokines. Future work is needed however, to provide a broader evidence-base for our claims to better inform designs to intervene in the higher workplace stress-poorer cognition relationship.
Competing Interests: The authors declare that they have no conflict of interest. This work was supported by 10.13039/501100009207AgriFutures Australia (formerly 10.13039/501100000982RIRDC), Racing Victoria Pty. Ltd, and a La Trobe University Postgraduate Research Scholarship.
(© 2022 The Authors.)
Databáze: MEDLINE
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