Systemic oxidative stress in children with cystic fibrosis with bacterial infection including Pseudomonas Aeruginosa.

Autor: Bennemann GD; Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil., Moreira EAM; Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil., Pereira LCR; Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., de Freitas MB; Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil., de Oliveira D; Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil., Ventura JC; Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil., Parisotto EB; School of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, Brazil., Moreno YMF; Department of Nutrition, Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil., Trindade EBSM; Department of Nutrition, Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil., Barbosa E; Joana de Gusmão Children's Hospital, Government of Santa Catarina, Florianópolis, Brazil., Ludwig Neto N; Joana de Gusmão Children's Hospital, Government of Santa Catarina, Florianópolis, Brazil., Wilhelm Filho D; Department of Ecology and Zoology, Graduate Program in Pharmacy, Federal University of Santa Catarina, Florianópolis, Brazil.
Jazyk: angličtina
Zdroj: The clinical respiratory journal [Clin Respir J] 2022 Jun; Vol. 16 (6), pp. 475-483. Date of Electronic Publication: 2022 Jun 26.
DOI: 10.1111/crj.13513
Abstrakt: Introduction: Oxidative stress (OS) occurs in cystic fibrosis (CF).
Objective: The objective of this work is to evaluate the influence of bacterial infection on biomarkers of OS (catalase [CAT], glutathione peroxidade [GPx], reduced glutathione [GSH]), markers of oxidative damage (protein carbonyls [PC], thiobarbituric acid reactive substances [TBARS]), together with the nutritional status and lung function in children with CF.
Methods: Cross-sectional study including CF group (CFG, n = 55) and control group (CG, n = 31), median age: 3.89 and 4.62 years, respectively. CFG was distributed into CFG negative bacteriology (CFGB-, n = 27) or CFG positive bacteriology (CFGB+, n = 28), and CFG negative Pseudomonas aeruginosa (CFGPa-, n = 36) or CFG positive Pseudomonas aeruginosa (CFGPa+, n = 19).
Results: Compared with CG, CFG (P = .034) and CFGB+ (P = .042) had lower body mass index-for-age z-score; forced expiratory volume in the first second was lower in CFGB+ and CFGPa+ (both P < .001). After adjusting for confounders and compared with CG: CFG showed higher TBARS (P ≤ .001) and PC (P = .048), and lower CAT (P = .004) and GPx (P = .003); the increase in PC levels was observed in CFGB+ (P = .011) and CFGPa+ (P = .001) but not in CFGB- (P = .510) and CFGPa- (P = .460).
Conclusions: These results indicate a systemic OS in children with CF. The presence of bacterial infection particularly Pseudomonas aeruginosa seems to be determinant to exacerbate the oxidative damage to proteins, in which PC may be a useful biomarker of OS in CF.
(© 2022 The Authors. The Clinical Respiratory Journal published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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