Structural and metabolic activity differences in serotonergic cell groups in a rat model of individual differences of emotionality and stress reactivity.

Autor: Glover ME; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA., Unroe KA; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA; Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA, USA., Moughnyeh MM; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA., McCoy C; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA., Kerman IA; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA; Behavioral Health Service Line, Veterans Affairs Pittsburgh Health System, Pittsburgh, PA 15240, USA., Clinton SM; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA. Electronic address: sclinton@vt.edu.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2022 Jul 27; Vol. 784, pp. 136752. Date of Electronic Publication: 2022 Jun 23.
DOI: 10.1016/j.neulet.2022.136752
Abstrakt: Serotonin regulates a diverse set of functions, including emotional behavior, cognition, sociability, appetite, and sleep. Serotonin is also a key trophic factor that shapes neurodevelopmental processes. Genetic and environmental factors that drive individual differences in the serotonergic system have the capacity to impact brain structure and behavior, and likely contribute to pathophysiological processes involved in neuropsychiatric disorders. Using adult rats selectively bred for low novelty exploration (Low Responders, LR), we previously demonstrated pronounced increases in the levels of their anxiety- and depression- relevant behaviors as compared to the selectively bred High Novelty Responder (HR) rats. These behavioral differences were accompanied by alterations in the expression of genes that regulate serotonin synthesis in the brainstem, and its signaling in the forebrain. The present study extends these observations with a focus on the organization and the metabolism of brainstem serotonin cell groups that provide serotonergic innervation of the hippocampus and other limbic regions of male HR/LR rats. Using design-based stereology, we found the median raphe (MnR) in adult male LR rats contains increased number of serotonergic neurons as compared to the HRs. This is preceded by an increase in the metabolic activity of the caudal dorsal raphe (DRC) and the intrafascicular DR (DRI) during early postnatal development. These findings suggest that structural and functional differences in the raphe-limbic projections shape behavioral inhibition throughout the lifespan.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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