Selenium nanoparticles impart robust neuroprotection against deltamethrin-induced neurotoxicity in male rats by reversing behavioral alterations, oxidative damage, apoptosis, and neuronal loss.

Autor: Khalil HMA; Veterinary Hygiene and Management Department, Faculty of Vet. Medicine, Cairo University, Giza 12211, Egypt. Electronic address: heba.ali315@gmail.com., Azouz RA; Toxicology and Forensic Medicine Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt., Hozyen HF; Animal Reproduction and Artificial Insemination Department, National Research Centre, Egypt., Aljuaydi SH; Biochemistry and Molecular biology department, Faculty of Vet. Medicine, Cairo University, Giza 12211, Egypt., AbuBakr HO; Biochemistry and Molecular biology department, Faculty of Vet. Medicine, Cairo University, Giza 12211, Egypt., Emam SR; Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt., Al-Mokaddem AK; Pathology Department, Faculty of Vet. Medicine, Cairo University, Giza 12211, Egypt.
Jazyk: angličtina
Zdroj: Neurotoxicology [Neurotoxicology] 2022 Jul; Vol. 91, pp. 329-339. Date of Electronic Publication: 2022 Jun 23.
DOI: 10.1016/j.neuro.2022.06.006
Abstrakt: This study investigated the neuroprotective role of selenium nanoparticles (SeNPs) on deltamethrin-induced neurotoxicity in rats. A total of 32 adult male Wister rats were allocated into the following four groups: 1) control, 2) deltamethrin (0.6 mg/kg), 3) SeNPs (0.5 mg/kg), and 4) deltamethrin + SeNPs. All agents were administered orally three times per week for 2 months. Locomotor behavior, anxiety-like behavior, biochemical parameters, including brain oxidative damage biomarkers (Malondialdehyde (MDA) and reduced glutathione (GSH)), brain acetylcholinesterase (AChE), and brain genotoxicity were evaluated. The gene expression levels of IGF-1 and Bcl 2 were also determined. Moreover, a brain histopathological examination associated with the immunohistochemical determination of Bax in brain tissue was performed. Deltamethrin-intoxicated rats showed a reduction in the locomotor activity associated with a highly anxious state. They also displayed a disturbance in the brain redox state with a decrease in the brain AChE levels and a high DNA fragmentation percentage. Furthermore, they showed a decrement in the immunohistochemical GFAP levels as well as IGF-1 and Bcl 2 gene expression levels with an increase in the immunohistochemical Bax levels. All these changes were confirmed by brain histopathology. Interestingly, SeNPs ameliorated all these changes and restored the normal brain architecture. In conclusion. SeNPs possess a potent medicinal activity due to their antioxidant and anti-inflammatory activity. Therefore, SeNPs can be a potential agent in ameliorating deltamethrin-induced neurotoxicity.
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Databáze: MEDLINE
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