Crosstalk between incretin hormones, Th17 and Treg cells in inflammatory diseases.

Autor: da Silva EM; Paulista School of Medicine, Federal University of São Paulo (UNIFESP), Brazil., Yariwake VY; Department of Immunology - Institute of Biomedical Sciences, University of São Paulo (USP), Brazil., Alves RW; Center for Natural and Human Sciences, Federal University of ABC (UFABC), Brazil., de Araujo DR; Center for Natural and Human Sciences, Federal University of ABC (UFABC), Brazil., Andrade-Oliveira V; Paulista School of Medicine, Federal University of São Paulo (UNIFESP), Brazil; Department of Immunology - Institute of Biomedical Sciences, University of São Paulo (USP), Brazil; Center for Natural and Human Sciences, Federal University of ABC (UFABC), Brazil. Electronic address: andrade.vinicius@ufabc.edu.br.
Jazyk: angličtina
Zdroj: Peptides [Peptides] 2022 Sep; Vol. 155, pp. 170834. Date of Electronic Publication: 2022 Jun 23.
DOI: 10.1016/j.peptides.2022.170834
Abstrakt: Intestinal epithelial cells constantly crosstalk with the gut microbiota and immune cells of the gut lamina propria. Enteroendocrine cells, secrete hormones, such as incretin hormones, which participate in host physiological events, such as stimulating insulin secretion, satiety, and glucose homeostasis. Interestingly, evidence suggests that the incretin pathway may influence immune cell activation. Consequently, drugs targeting the incretin hormone signaling pathway may ameliorate inflammatory diseases such as inflammatory bowel diseases, cancer, and autoimmune diseases. In this review, we discuss how these hormones may modulate two subsets of CD4 + T cells, the regulatory T cells (Treg)/Th17 axis important for gut homeostasis: thus, preventing the development and progression of inflammatory diseases. We also summarize the main experimental and clinical findings using drugs targeting the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP-1) signaling pathways and their great impact on conditions in which the Treg/Th17 axis is disturbed such as inflammatory diseases and cancer. Understanding the role of incretin stimulation in immune cell activation and function, might contribute to new therapeutic designs for the treatment of inflammatory diseases, autoimmunity, and tumors.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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