Characteristics and outcomes of vaccinated and nonvaccinated patients hospitalized in a single Italian hub for COVID-19 during the Delta and Omicron waves in Northern Italy.

Autor:	Rovida F; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy., Esposito GL; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Specialization School in Microbiology and Virology, University of Pavia, Pavia, Italy., Rissone M; Medical Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Public Health, Experimental and Forensic Medicine, Section of Hygiene, University of Pavia, Pavia, Italy., Novelli V; Medical Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Cutti S; Medical Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Muzzi A; Medical Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Rona C; Medical Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Bertoli E; Medical Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Daglio M; Medical Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Piralla A; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Paolucci S; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Campanini G; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Ferrari G; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Specialization School in Microbiology and Virology, University of Pavia, Pavia, Italy., Giardina F; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Zavaglio F; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Lilleri D; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: d.lilleri@smatteo.pv.it., Grugnetti AM; Health Professions Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Grugnetti G; Health Professions Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Odone A; Department of Public Health, Experimental and Forensic Medicine, Section of Hygiene, University of Pavia, Pavia, Italy., Marena C; Medical Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Baldanti F; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2022 Sep; Vol. 122, pp. 420-426. Date of Electronic Publication: 2022 Jun 22.
DOI:	10.1016/j.ijid.2022.06.028
Abstrakt:	Objective: We compared the characteristics and outcomes of vaccinated and nonvaccinated patients hospitalized with COVID-19. Design: We analyzed patients hospitalized in a COVID hub during three one-month periods: (i) October 15, 2020-November 15, 2020 (prevaccination peak); (ii) October 15, 2021-November 15, 2021 (Delta wave); (iii) December 15, 2021-January 15, 2022 (Omicron wave). To define the epidemiologic context, SARS-CoV-2 infection in healthcare workers was analyzed. Results: SARS-CoV-2 infection incidence in healthcare workers was 146 cases per 1000 persons in 2020 (prevaccination) and 67 in 2021 (postvaccination, when the Omicron variant caused most infections). There were 420 hospitalized patients in the prevaccination period, 51 during the Delta wave (52.1% vaccinated) and 165 during the Omicron wave (52.9% vaccinated). During the Delta wave, a significantly higher number of nonvaccinated (29.2%) than vaccinated patients (3.7%) were admitted to the intensive care unit (ICU) (p = 0.019). Nonvaccinated patients were younger and had a lower rate of concomitant medical conditions (53.2% vs 83.7%; p < 0.001) during the Omicron wave when 80% of patients admitted to ICU and all those who died were still infected by the Delta variant. Conclusions: Vaccine effectiveness in fragile individuals appears to be lower because of a faster immunity decline. However, the Omicron variant seems to cause less severe COVID-19. Competing Interests: Conflicts of interest The authors have no competing interests to declare. (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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