Impact of community-based exercise on fatigue in early breast cancer survivors: identifying potential determinants of change.

Autor: Wagoner CW; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. chad.wagoner@ucalgary.ca.; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. chad.wagoner@ucalgary.ca.; Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, Calgary, AB, T2N IN4, Canada. chad.wagoner@ucalgary.ca., Lee JT; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hanson ED; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kerr ZY; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Matthew Gfeller Sport-Related TBI Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Nyrop KA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Muss HB; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Battaglini CL; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jazyk: angličtina
Zdroj: Breast cancer (Tokyo, Japan) [Breast Cancer] 2022 Nov; Vol. 29 (6), pp. 1001-1012. Date of Electronic Publication: 2022 Jun 24.
DOI: 10.1007/s12282-022-01380-y
Abstrakt: Background: Exercise has been shown to reduce fatigue in early breast cancer survivors (EBCS), though it is unclear if these results translate to community-based exercise settings. Mechanisms that influence changes in fatigue seen after exercise are also poorly understood. This study sought to evaluate the impact of community-based exercise and identify associations of fatigue in EBCS.
Methods: Twenty-nine EBCS and 13 non-cancer controls (CON) enrolled. Pre/post-intervention measurements included measures of fitness/function, balance, and adherence/compliance as well as self-reported measures of fatigue, health-related quality of life (HRQOL), well-being, self-efficacy, and physical activity. Both groups participated in a supervised 16-week aerobic + resistance exercise intervention. A mixed model ANOVA and Cohen's D effect size assessed fatigue changes, and univariable linear regressions identified fatigue associations.
Results: Fatigue improved for EBCS (- 2.6, Cohen's D = 0.51) but not CON (0.0, Cohen's D = 0.02); no interaction effect was observed. Post-intervention fatigue in EBCS was associated with better QOL (R 2  = 0.387; p < 0.01), depression (R 2  = 0.251; p < 0.01), self-efficacy, (R 2  = 0.453; p < 0.01), outcome expectations from exercise (R 2  = 0.254; p < 0.01), balance (R 2  = 0.167; p < 0.05), and the 6-minute walk test (R 2  = 0.193; p < 0.05). EBCS improvements in fatigue were associated with improvements in self-reported physical health (R 2  = 0.425; p < 0.01), depression (R 2  = 0.233; p < 0.01), pain (R 2  = 0.157; p < 0.05), outcome expectations from exercise (R 2  = 0.420; p < 0.01), and the 6-minute walk test (R 2  = 0.172; p < 0.05). Less fatigue in the CON group was shown be associated with better sleep quality (R 2  = 0.309; p < 0.05) and pain (R 2  = 0.259; p < 0.05).
Conclusion: Community-based exercise appears beneficial for alleviating fatigue in EBCS. These improvements may be driven by parallel improvements in psychosocial outcomes and objectively measured functional outcomes.
(© 2022. The Author(s), under exclusive licence to The Japanese Breast Cancer Society.)
Databáze: MEDLINE
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