Incidence and management of pleural effusions in patients with Wilms tumor: A Pediatric Surgical Oncology Research Collaborative study.

Autor: Al-Hadidi A; Department of Surgery, Division of Pediatric Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA., Rinehardt HN; Division of Pediatric General and Thoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Sutthatarn P; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Talbot LJ; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Murphy AJ; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Whitlock R; Division of Pediatric Surgery, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA., Condon S; Division of Pediatric Surgery, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA., Naik-Mathuria B; Division of Pediatric Surgery, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA., Utria AF; Seattle Children's Hospital, University of Washington, Seattle, Washington, USA., Rothstein DH; Seattle Children's Hospital, University of Washington, Seattle, Washington, USA., Chen SY; Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Wong-Michalak S; Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Kim ES; Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Short SS; Primary Children's Hospital, University of Utah, Salt Lake City, Utah, USA., Meyers RL; Primary Children's Hospital, University of Utah, Salt Lake City, Utah, USA., Kastenberg ZJ; Primary Children's Hospital, University of Utah, Salt Lake City, Utah, USA., Johnston ME 2nd; Division of Pediatric General and Thoracic Surgery Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Zens T; Division of Pediatric General and Thoracic Surgery Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Dasgupta R; Division of Pediatric General and Thoracic Surgery Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Malek MM; Division of Pediatric General and Thoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Calabro K; Centre Hospitalier Universitaire Ste-Justine, Université de Montréal, Montréal, Quebec, Canada., Piché N; Centre Hospitalier Universitaire Ste-Justine, Université de Montréal, Montréal, Quebec, Canada., Callas H; Ann & Robert H Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois, USA., Lautz TB; Ann & Robert H Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois, USA., McKay K; Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Lovvorn HN 3rd; Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Commander SJ; Department of Surgery, Division of Pediatric Surgery, Duke University Medical Center, Durham, North Carolina, USA., Tracy ET; Department of Surgery, Division of Pediatric Surgery, Duke University Medical Center, Durham, North Carolina, USA., Lund SB; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Polites SF; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Davidson J; Department of Surgery, Division of Paediatric Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada., Dhooma J; Department of Surgery, Division of Paediatric Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada., Seemann NM; Department of Surgery, Division of Paediatric Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada., Marquart JP; Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Gainer H; Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Lal DR; Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Rich BS; Division of Pediatric Surgery, Cohen Children's Medical Center, Northwell Health, New Hyde Park, New York, USA., Glick RD; Division of Pediatric Surgery, Cohen Children's Medical Center, Northwell Health, New Hyde Park, New York, USA., Maloney L; Department of Surgery, Division of Pediatric Surgery, Oregon Health and Science University, Portland, Oregon, USA., Radu S; Department of Surgery, Division of Pediatric Surgery, Oregon Health and Science University, Portland, Oregon, USA., Fialkowski EA; Department of Surgery, Division of Pediatric Surgery, Oregon Health and Science University, Portland, Oregon, USA., Kwok PE; Departments of Surgery and Urology, IWK Health, Dalhousie University, Halifax, Nova Scotia, Canada., Romao RLP; Departments of Surgery and Urology, IWK Health, Dalhousie University, Halifax, Nova Scotia, Canada., Rubalcava N; University of Michigan Section of Pediatric Surgery, Ann Arbor, Michigan, USA., Ehrlich PF; University of Michigan Section of Pediatric Surgery, Ann Arbor, Michigan, USA., Newman E; University of Michigan Section of Pediatric Surgery, Ann Arbor, Michigan, USA., Diehl T; American Family Children's Hospital, University of Wisconsin-Madison, Madison, Wisconsin, USA., Le HD; American Family Children's Hospital, University of Wisconsin-Madison, Madison, Wisconsin, USA., Polcz V; Division of Pediatric Surgery, University of Florida, Gainesville, Florida, USA., Petroze RT; Division of Pediatric Surgery, University of Florida, Gainesville, Florida, USA., Stanek J; Department of Surgery, Division of Pediatric Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA., Aldrink JH; Department of Surgery, Division of Pediatric Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2022 Nov 15; Vol. 151 (10), pp. 1696-1702. Date of Electronic Publication: 2022 Jul 14.
DOI: 10.1002/ijc.34188
Abstrakt: Wilms tumor (WT) is the most common renal malignancy in children. Children with favorable histology WT achieve survival rates of over 90%. Twelve percent of patients present with metastatic disease, most commonly to the lungs. The presence of a pleural effusion at the time of diagnosis of WT may be noted on staging imaging; however, minimal data exist regarding the significance and prognostic importance of this finding. The objectives of our study are to identify the incidence of pleural effusions in patients with WT, and to determine the potential impact on oncologic outcomes. A multi-institutional retrospective review was performed from January 2009 to December 2019, including children with WT and a pleural effusion on diagnostic imaging treated at Pediatric Surgical Oncology Research Collaborative (PSORC) participating institutions. Of 1259 children with a new WT diagnosis, 94 (7.5%) had a pleural effusion. Patients with a pleural effusion were older than those without (median 4.3 vs 3.5 years; P = .004), and advanced stages were more common (local stage III 85.9% vs 51.9%; P < .0001). Only 14 patients underwent a thoracentesis for fluid evaluation; 3 had cytopathologic evidence of malignant cells. Event-free and overall survival of all children with WT and pleural effusions was 86.2% and 91.5%, respectively. The rate and significance of malignant cells present in pleural fluid is unknown due to low incidence of cytopathologic analysis in our cohort; therefore, the presence of an effusion does not appear to necessitate a change in therapy. Excellent survival can be expected with current stage-specific treatment regimens.
(© 2022 UICC.)
Databáze: MEDLINE
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