Long-term cognitive and functional status in Danish ICU patients with COVID-19.

Autor: Weihe S; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark., Mortensen CB; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark., Haase N; Department of Intensive Care, Rigshospitalet, Copenhagen, Denmark., Andersen LPK; Department of Anesthesiology and Intensive Care, Bispebjerg Hospital, Copenhagen, Denmark., Mohr T; Department of Anesthesiology and Intensive Care, Herlev-Gentofte Hospital, Copenhagen, Denmark., Siegel H; Department of Anesthesiology and Intensive Care, Herlev-Gentofte Hospital, Copenhagen, Denmark., Ibsen M; Department of Anesthesiology and Intensive Care, North Zealand Hospital, Hillerød, Denmark., Jørgensen VRL; Department of Cardiothoracic Anesthesiology, Rigshospitalet, Copenhagen, Denmark., Buck DL; Department of Anesthesiology and Intensive Care, Holbaek Hospital, Holbaek, Denmark., Pedersen HBS; Department of Anesthesiology and Intensive Care, Nykøbing Falster Hospital, Nykøbing Falster, Denmark., Pedersen HP; Department of Anesthesiology and Intensive Care, Zealand University Hospital, Roskilde, Denmark., Iversen S; Department of Anesthesiology and Intensive Care, Slagelse Hospital, Slagelse, Denmark., Ribergaard N; Department of Anesthesiology and Intensive Care, Hjørring Hospital, Hjørring, Denmark., Rasmussen BS; Department of Anesthesiology and Intensive Care, Aalborg University Hospital, Aalborg, Denmark., Winding R; Department of Anesthesiology and Intensive Care, Herning Hospital, Herning, Denmark., Espelund US; Department of Anesthesiology and Intensive Care, Horsens Hospital, Horsens, Denmark., Bundgaard H; Department of Anesthesiology and Intensive Care, Randers Hospital, Randers, Denmark., Sølling CG; Department of Anesthesiology and Intensive Care, Viborg Hospital, Viborg, Denmark., Christensen S; Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Garcia RS; Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg, Denmark., Brøchner AC; Department of Anesthesiology and Intensive Care, Kolding Hospital, Kolding, Denmark., Michelsen J; Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark., Michagin G; Department of Anesthesiology and Intensive Care, Svendborg Hospital, Svendborg, Denmark., Kirkegaard L; Department of Anesthesiology and Intensive Care, Aabenraa Hospital, Aabenraa, Denmark., Perner A; Department of Intensive Care, Rigshospitalet, Copenhagen, Denmark., Mathiesen O; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark., Poulsen LM; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.
Jazyk: angličtina
Zdroj: Acta anaesthesiologica Scandinavica [Acta Anaesthesiol Scand] 2022 Sep; Vol. 66 (8), pp. 978-986. Date of Electronic Publication: 2022 Jul 13.
DOI: 10.1111/aas.14108
Abstrakt: Background: ICU admission due to COVID-19 may result in cognitive and physical impairment. We investigated the long-term cognitive and physical status of Danish ICU patients with COVID-19.
Methods: We included all patients with COVID-19 admitted to Danish ICUs between March 10 and May 19, 2020. Patients were the contacted prospectively at 6 and 12 months for follow-up. Our primary outcomes were cognitive function and frailty at 6 and 12 months after ICU admission, estimated by the Mini Montreal Cognitive Assessment, and the Clinical Frailty Scale. Secondary outcomes were 6- and 12-month mortality, health-related quality of life (HRQoL) assessed by EQ-5D-5L, functional status (Barthel activities of daily living and Lawton-Brody instrumental activities of daily living), and fatigue (Fatigue Assessment Scale). The study had no information on pre-ICU admission status for the participants.
Results: A total of 326 patients were included. The 6- and 12-month mortality was 37% and 38%, respectively. Among the 204 six-month survivors, 105 (51%) participated in the 6-month follow-up; among the 202 twelve-month survivors, 95 (47%) participated in the 12-month follow-up. At 6 months, cognitive scores indicated impairment for 26% (95% confidence interval [CI], 11.4-12.4) and at 12 months for 17% (95% CI, 12.0-12.8) of participants. Frailty was indicated in 20% (95% CI, 3.4-3.9) at 6 months, and for 18% (95% CI, 3.3-3.8) at 12 months. Fatigue was reported by 52% at 6 months, and by 47% at 12 months. For HRQoL, moderate, severe, or extreme health problems were reported by 28% at 6 months, and by 25% at 12 months.
Conclusion: Long-term cognitive, functional impairment was found in up to one in four of patients surviving intensive care for COVID-19. Fatigue was present in nearly half the survivors at both 6 and 12 months. However, pre-ICU admission status of the patients was unknown.
(© 2022 Acta Anaesthesiologica Scandinavica Foundation.)
Databáze: MEDLINE
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