NOS3 rs1799983 and rs2070744 polymorphisms and their association with advanced chronic kidney disease and coronary heart disease in Canarian population with type 2 diabetes.

Autor: Boronat M; Instituto Universitario de Investigaciones Biomédicas y Sanitarias, University of Las Palmas de Gran Canaria, Faculty of Health Sciences, Spain.; Section of Endocrinology and Nutrition, University of Las Palmas de Gran Canaria, Faculty of Health Sciences, Spain., Tugores A; Research Unit, University of Las Palmas de Gran Canaria, Faculty of Health Sciences, Spain., Saavedra P; Mathematics Department - Complejo Hospitalario Materno-Insular, University of Las Palmas de Gran Canaria, Faculty of Health Sciences, Spain., Garay P; Section of Endocrinology and Nutrition, University of Las Palmas de Gran Canaria, Faculty of Health Sciences, Spain., Bosch E; Service of Nephrology University of Las Palmas de Gran Canaria, Faculty of Health Sciences, Spain., Lorenzo D; Universidad Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain., Ibarra A; Section of Endocrinology and Nutrition, University of Las Palmas de Gran Canaria, Faculty of Health Sciences, Spain., García-Cantón C; Service of Nephrology University of Las Palmas de Gran Canaria, Faculty of Health Sciences, Spain.
Jazyk: angličtina
Zdroj: Acta endocrinologica (Bucharest, Romania : 2005) [Acta Endocrinol (Buchar)] 2021 Oct-Dec; Vol. 17 (4), pp. 440-448.
DOI: 10.4183/aeb.2021.440
Abstrakt: Context: Different polymorphisms of the endothelial nitric oxide synthase gene (NOS3) have been related to diabetic kidney disease.
Objective: To evaluate the association between advanced diabetic chronic kidney disease (ACKD) and the rs1799983 and rs2070744 poymorphisms of NOS3 in a population from the Gran Canaria island.
Design: Cross-sectional case-control study.
Subjects and Methods: Polymorphisms were genotyped in 152 subjects with ACKD secondary to type 2 diabetes [estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m 2 ], 110 subjects with type 2 diabetes for 20 or more years since diagnosis without ACKD (eGFR ≥45 mL/min/1.73m 2 and albumin/creatinine ratio <300 mg/g and/or 24-h urinary albumin excretion <300 mg) and 292 healthy controls. Association between both polymorphisms and established coronary heart disease (CHD) was also analyzed in both groups with diabetes.
Results: A greater proportion of homozygous individuals for the risk allele C of rs2070744 was found among subjects with ACKD. Association between ACKD and rs2070744 was observed in a recessive genetic model, both for comparison to subjects with diabetes but no ACKD [OR 2.17 (95% CI: 1.17-4.00), p=0.014] and for comparison to healthy controls [OR 1.61 (1.03-2.52), p=0.036]. The frequency of the C allele was significantly higher among subjects with CHD, but only in the group with ACKD. No associations were found for rs1799983.
Conclusions: NOS3 rs2070744 is associated with ACKD in population with type 2 diabetes from Gran Canaria. A link between this genetic variant and CHD in Canarian subjects with type 2 diabetes could be restricted to cases with ACKD.
Competing Interests: The authors declare that they have no conflict of interest.
(©2021 Acta Endocrinologica (Buc).)
Databáze: MEDLINE
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