Daptomycin-Associated Diarrhea: A Case Report and Review of the Literature.

Autor:	Awadelkarim AM; Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA., Idris I; Pediatrics, Woodhull Medical Center, New York, USA., Abdelhai M; Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA., Yeddi A; Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA., Saad E; Internal Medicine, Saint Francis Hospital, Evanston, USA., Alhusain R; Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA., Dayco J; Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA., Ali M; Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA., Salih L; Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Jun 20; Vol. 14 (6), pp. e26135. Date of Electronic Publication: 2022 Jun 20 (Print Publication: 2022).
DOI:	10.7759/cureus.26135
Abstrakt:	Antibiotic-associated diarrhea (AAD) describes any unexplained diarrhea associated with the use of antibiotics. AAD develops through diverse mechanisms, ranging from pharmacologic effects on gut motility to disturbance of the function and carbohydrate metabolism of the indigenous intestinal flora and overgrowth by pathogenic micro-organisms. Clostridioides difficile-associated diarrhea (CDAD) is a subset of AAD; however, it accounts only for a small percentage of diarrhea caused by antibiotics. Diarrhea has been reported as a side effect of daptomycin use, nevertheless, it's thought to be mild and carries significantly less risk of diarrhea than other alternative treatments of S. aureus bacteremia, i.e., vancomycin or cefazolin. The authors present an interesting case of daptomycin-associated diarrhea presenting with a protracted and severe course. Patient symptoms didn't improve with empiric Clostridioides difficile therapy and CDAD testing was negative. Diarrhea promptly resolved after discontinuation of daptomycin. Furthermore, a thorough literature review was conducted and discussed in this article to raise awareness of this under-recognized complication. Clinicians should be mindful of daptomycin-associated diarrhea along with its presentation and treatment. Further studies are needed to identify the pathophysiology of daptomycin-associated diarrhea and other forms of AAD. Understanding their mechanism could help prevent, treat, and reduce the significant medical costs associated with antibiotic adverse events. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Awadelkarim et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu