Sputnik V Effectiveness against Hospitalization with COVID-19 during Omicron Dominance.

Autor: Shkoda AS; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Gushchin VA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Virology, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia., Ogarkova DA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Stavitskaya SV; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Orlova OE; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Kuznetsova NA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Keruntu EN; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Pochtovyi AA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Virology, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia., Pukhov AV; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Kleymenov DA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Krzhanovsky VG; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Vasina DV; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Shkuratova NV; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Shidlovskaya EV; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Gorbunov AL; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Kustova DD; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Virology, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia., Mazurina EA; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Kozlova SR; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Soboleva AV; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Grigoriev IV; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Pankratyeva LL; City Clinical Hospital No. 67 Named after. L.A. Vorokhobov of the Moscow City Department, 123423 Moscow, Russia., Odintsova AS; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Belyaeva ED; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Virology, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia., Bessonova AA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Vasilchenko LA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Lupu IP; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Adgamov RR; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Tkachuk AP; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Tokarskaya EA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Logunov DY; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Gintsburg AL; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Infectiology and Virology, Federal State Autonomous Educational Institution of Higher Education I M Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119435 Moscow, Russia.
Jazyk: angličtina
Zdroj: Vaccines [Vaccines (Basel)] 2022 Jun 13; Vol. 10 (6). Date of Electronic Publication: 2022 Jun 13.
DOI: 10.3390/vaccines10060938
Abstrakt: Mass vaccination campaigns against COVID-19 affected more than 90% of the population in most developed countries. The new epidemiologic wave of COVID-19 has been ongoing since the end of 2021. It is caused by a virus variant B.1.1.529, also known as "Omicron" and its descendants. The effectiveness of major vaccines against Omicron is not known. The purpose of this study is to evaluate the efficacy of the Sputnik V vaccine. The main goal is to assess its protection against hospitalization in the period of Omicron dominance. We conducted our study based on a large clinical center in Moscow (Russia) where 1112 patients were included. We used the case-population method to perform the calculations. The data we obtained indicate that the Omicron variant causes at least 90% of infections in the studied cohort. The effectiveness of protection against hospitalization with COVID-19 in our study was 85.9% (95% CI 83.0-88.0%) for those who received more than one dose. It was 87.6% (95% CI 85.4-89.5%) and 97.0% (95% CI 95.9-97.8%) for those who received more than two or three doses. The effectiveness in cases of more severe forms was higher than for less severe ones. Thus, present study indicates the high protective efficacy of vaccination against hospitalization with COVID-19 in case of Omicron lineage.
Databáze: MEDLINE
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