Antiseptic Polymer-Surfactant Complexes with Long-Lasting Activity against SARS-CoV-2.

Autor: Molchanov VS; Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russia., Shibaev AV; Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russia., Karamov EV; Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.; National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Russian Ministry of Health, 127473 Moscow, Russia., Larichev VF; Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia., Kornilaeva GV; Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia., Fedyakina IT; Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia., Turgiev AS; Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.; National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Russian Ministry of Health, 127473 Moscow, Russia., Philippova OE; Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russia., Khokhlov AR; Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: Polymers [Polymers (Basel)] 2022 Jun 16; Vol. 14 (12). Date of Electronic Publication: 2022 Jun 16.
DOI: 10.3390/polym14122444
Abstrakt: Antiseptic polymer gel-surfactant complexes were prepared by incorporating the low-molecular-weight cationic disinfectant cetylpyridinium chloride into the oppositely charged, slightly cross-linked polymer matrices. Three types of polymers were used: copolymers of acrylamide and sodium 2-acrylamido-2-methylpropane sulfonate; copolymers of acrylamide and sodium methacrylate; copolymers of vinylpyrrolidone and sodium methacrylate. It was shown that the rate of the release of the cationic disinfectant from the oppositely charged polymer gels could be tuned in a fairly broad range by varying the concentration of the disinfectant, the degree of swelling, and degree of cross-linking of the gel and the content/type of anionic repeat units in the polymer matrix. Polymer-surfactant complexes were demonstrated to reduce SARS-CoV-2 titer by seven orders of magnitude in as little as 5 s. The complexes retained strong virucidal activity against SARS-CoV-2 for at least one week.
Databáze: MEDLINE
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