| Autor: |
Hodel KVS; SENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, Brazil.; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil., Machado BAS; SENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, Brazil., Sacramento GDC; SENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, Brazil., Maciel CAO; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil., Oliveira-Junior GS; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil., Matos BN; Laboratory of Medicines, Food and Cosmetics (LTMAC), University of Brasília, Brasilia 70910-900, Brazil., Gelfuso GM; Laboratory of Medicines, Food and Cosmetics (LTMAC), University of Brasília, Brasilia 70910-900, Brazil., Nunes SB; SENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, Brazil., Barbosa JDV; SENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, Brazil., Godoy ALPC; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. |
| Abstrakt: |
The use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector's main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with green and red propolis extract (2 to 4%) and the active compounds p -coumaric acid and biochanin A (8 to 16 mg). The characterization of the nine developed samples (one control and eight active wound dressings) evidenced that the mechanics, physics, morphological, and barrier properties depended not only on the type of active principle incorporated onto the cellulosic matrix, but also on its concentration. Of note were the results found for transparency (28.59-110.62T 600 mm -1 ), thickness (0.023-0.046 mm), swelling index (48.93-405.55%), water vapor permeability rate (7.86-38.11 g m 2 day -1 ), elongation (99.13-262.39%), and antioxidant capacity (21.23-86.76 μg mL -1 ). The wound dressing based on BC and red propolis was the only one that presented antimicrobial activity. The permeation and retention test revealed that the wound dressing containing propolis extract presented the most corneal stratum when compared with viable skin. Overall, the developed wound dressing showed potential to be used for treatment against different types of dermal lesions, according to its determined proprieties. |
