| Autor: |
do Nascimento JR; Institut of Biosciences, Coastal Campus of São Vicente, Universidade Estadual Paulista-UNESP, São Vicente 11330-900, SP, Brazil., de Jesus Alves Miranda A; Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil., Vieira FC; Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil., Rodrigues CDP; Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil., Vasconcelos LN; Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil., Filho JLP; Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil., Lopes ACCB; Biodiversity and Biotechnology Graduate Program-BIONORTE, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil., Tangerina MMP; Botany Department, Institute of Biosciences, University of São Paulo-USP, São Paulo 05508-090, SP, Brazil., Vilegas W; Institut of Biosciences, Coastal Campus of São Vicente, Universidade Estadual Paulista-UNESP, São Vicente 11330-900, SP, Brazil., da Rocha CQ; Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil.; Biodiversity and Biotechnology Graduate Program-BIONORTE, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil. |
| Abstrakt: |
The genus Arrabidaea, consisting of ~170 species, belongs to the family Bignoniaceae, distributed around the Neotropics and temperate zone. The center of diversity of the family is in Brazil, where 56 genera and about 340 species exist. Most species of the genus Arrabidaea are traditionally utilized as diuretics and antiseptics, as well as for treating intestinal colic, diarrhea, kidney stones, rheumatoid arthritis, wounds, and enterocolitis. The genus is chemically diverse with different substance classes; most of them are triterpenes, phenolic acids, and flavonoids, and they exhibit valuable pharmacological properties, such as antitumor, antioxidant, leishmanicidal, trypanocidal, anti-inflammatory, and healing properties. This review presents information on the chemical constituents isolated from seven Arrabidaea species, and the pharmacological activities of the extracts, fractions and pure substances isolated since 1994, obtained from electronic databases. The various constituents present in the different species of this genus demonstrate a wide pharmacological potential for the development of new therapeutic agents, however its potential has been underestimated. |
