Multifunctional Hybrid MoS 2 -PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine.

Autor: Malagrino TRS; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil., Godoy AP; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil., Barbosa JM; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil., Lima AGT; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil., Sousa NCO; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil., Pedrotti JJ; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil., Garcia PS; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil., Paniago RM; Departamento de Física, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6.627, Belo Horizonte 31270-901, MG, Brazil., Andrade LM; Departamento de Física, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6.627, Belo Horizonte 31270-901, MG, Brazil., Domingues SH; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil.; MackGraphe, Mackenzie Institute for Advanced Research in Graphene and Nanotechnologies, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil., Silva WM; Departamento de Química, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6.627, Belo Horizonte 31270-901, MG, Brazil., Ribeiro H; Engineering School, Mackenzie Presbyterian University, Rua da Consolação 896, São Paulo 01302-907, SP, Brazil., Taha-Tijerina J; Engineering Department, Universidad de Monterrey, Av. Ignacio Morones Prieto 4500 Pte., San Pedro Garza García 66238, NL, Mexico.; Engineering Technology Department, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.
Jazyk: angličtina
Zdroj: Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2022 Jun 15; Vol. 12 (12). Date of Electronic Publication: 2022 Jun 15.
DOI: 10.3390/nano12122053
Abstrakt: In this work, flower-like molybdenum disulfide (MoS 2 ) microspheres were produced with polyethylene glycol (PEG) to form MoS 2 -PEG. Likewise, gold nanoparticles (AuNPs) were added to form MoS 2 -PEG/Au to investigate its potential application as a theranostic nanomaterial. These nanomaterials were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), photoelectron X-ray spectroscopy (XPS), Fourier-transformed infrared spectroscopy (FTIR), cyclic voltammetry and impedance spectroscopy. The produced hierarchical MoS 2 -PEG/Au microstructures showed an average diameter of 400 nm containing distributed gold nanoparticles, with great cellular viability on tumoral and non-tumoral cells. This aspect makes them with multifunctional characteristics with potential application for cancer diagnosis and therapy. Through the complete morphological and physicochemical characterization, it was possible to observe that both MoS 2 -PEG and MoS 2 -PEG/Au showed good chemical stability and demonstrated noninterference in the pattern of the cell nucleus, as well. Thus, our results suggest the possible application of these hybrid nanomaterials can be immensely explored for theranostic proposals in biomedicine.
Databáze: MEDLINE
Externí odkaz: