Autor: |
Ghelardi E; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy., Abreu Y Abreu AT; Gastroenterology and Neuroenterology and Motility, Hospital Angeles del Pedregal, Mexico City 10700, Mexico., Marzet CB; Paediatric Gastroenterology and Nutrition Section, Hospital General de Agudos 'Dr. Ignacio Pirovano', Buenos Aires C1428, Argentina., Álvarez Calatayud G; Section of Pediatric Gastroenterology and Nutrition, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Perez M 3rd; Sanofi, 65929 Frankfurt, Germany., Moschione Castro AP; Allergy and Immunology Division, Pediatric Department, Faculdade de Medicina, Instituto da Criança e do Adolescente, Hospital das Clínicas, Universidade de São Paulo (HC-FMUSP), São Paulo 05403-000, Brazil. |
Abstrakt: |
Bacillus clausii is a probiotic that benefits human health. Its key characteristics include the ability to form spores; the resulting tolerance to heat, acid, and salt ensures safe passage through the human gastrointestinal tract with no loss of cells. Although B . clausii has been widely used for many decades, the beneficial properties of other probiotics, such as Lactobacillus spp. and Bifidobacterium spp., are better disseminated in the literature. In this review, we summarize the physiological, antimicrobial, and immunomodulatory properties of probiotic B . clausii strains. We also describe findings from studies that have investigated B . clausii probiotics from the perspective of quality and safety. We highlight innovative properties based on biochemical investigations of non-probiotic strains of B . clausii , revealing that B . clausii may have further health benefits in other therapeutic areas. |