| Autor: |
Bakun P; Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.; Doctoral School, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland., Czarczynska-Goslinska B; Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland., Mlynarczyk DT; Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland., Musielak M; Doctoral School, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland.; Department of Electroradiology, Poznan University of Medical Sciences, Garbary 15, 61-866 Poznan, Poland., Mylkie K; Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland., Dlugaszewska J; Chair and Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Swiecickiego 4, 60-781 Poznan, Poland., Koczorowski T; Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland., Suchorska WM; Department of Electroradiology, Poznan University of Medical Sciences, Garbary 15, 61-866 Poznan, Poland., Ziegler-Borowska M; Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland., Goslinski T; Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland., Krakowiak R; Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.; Doctoral School, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland. |
| Abstrakt: |
Wound healing and skin tissue regeneration remain the most critical challenges faced by medical professionals. Titanium(IV) oxide-based materials were proposed as components of pharmaceutical formulations for the treatment of difficult-to-heal wounds and unsightly scarring. A gallic acid-functionalized TiO 2 nanomaterial (TiO 2 -GA) was obtained using the self-assembly technique and characterized using the following methods: scanning electron microscopy (SEM), transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), X-ray powder diffraction (XRPD), infrared spectroscopy (IR), Raman spectroscopy and thermogravimetry (TG). Additionally, physicochemical and biological tests (DPPH assay, Microtox ® acute toxicity test, MTT assay) were performed to assess antioxidant properties as well as to determine the cytotoxicity of the novel material against eukaryotic (MRC-5 pd19 fibroblasts) and prokaryotic ( Staphylococcus aureus, Escherichia coli, Candida albicans, Aliivibrio fischeri ) cells. To determine the photocytotoxicity of the material, specific tests were carried out with and without exposure to visible light lamps (425 nm). Following the results, the TiO 2 -GA material could be considered an additive to dressings and rinsing suspensions for the treatment of difficult-to-heal wounds that are at risk of bacterial infections. |
