Alzheimer's Disease CSF Biomarker Profiles in Idiopathic Normal Pressure Hydrocephalus.

Autor:	Mazzeo S; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy., Emiliani F; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy., Bagnoli S; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy., Padiglioni S; Regional Referral Centre for Relational Criticalities, 50139 Florence, Italy.; Research and Innovation Centre for Dementia-CRIDEM, Careggi University Hospital, 50134 Florence, Italy., Del Re LM; Research Unit of Medicine Ageing, Department of Experimental and Clinical Medicine, University of Florence, 50121 Florence, Italy., Giacomucci G; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy., Balestrini J; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy., Ingannato A; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy., Moschini V; Dipartimento Neuromosucolo-Scheletrico e Degli Organi di Senso, Careggi University Hospital, 50134 Florence, Italy., Morinelli C; Dipartimento Neuromosucolo-Scheletrico e Degli Organi di Senso, Careggi University Hospital, 50134 Florence, Italy., Galdo G; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy., Polito C; IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy., Ferrari C; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy., Pansini G; Neurosurgery Unit, Careggi University Hospital, Largo Giovanni Alessandro Brambilla 3, 50134 Florence, Italy., Della Puppa A; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy., Bessi V; Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla, 3, 50134 Florence, Italy.; Research and Innovation Centre for Dementia-CRIDEM, Careggi University Hospital, 50134 Florence, Italy.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2022 Jun 06; Vol. 12 (6). Date of Electronic Publication: 2022 Jun 06.
DOI:	10.3390/jpm12060935
Abstrakt:	Patients with idiopathic normal pressure hydrocephalus (iNPH) frequently show pathologic CSF Aβ 42 levels, comparable with Alzheimer's Disease (AD). Nevertheless, the clinical meaning of these findings has not been fully explained. We aimed to assess the role of AD CSF biomarkers (Aβ 42 , Aβ 42 /Aβ 40 , p-tau, t-tau) in iNPH. To this purpose, we enrolled 44 patients diagnosed with iNPH and 101 with AD. All the patients underwent CSF sampling. We compared CSF biomarker levels in iNPH and AD: Aβ 42 levels were not different between iNPH and AD, while Aβ 42 /Aβ 40 , p-tau, and t-tau were significantly different and showed excellent accuracy in distinguishing iNPH and AD. A multiple logistic regression analysis showed that Aβ 42 /Aβ 40 was the variable that most contributed to differentiating the two groups. Furthermore, iNPH patients with positive Aβ 42 /Aβ 40 had higher p-tau and t-tau than iNPH patients with negative Aβ 42 /Aβ 40 . Those iNPH patients who showed cognitive impairment had lower Aβ 42 /Aβ 40 and higher p-tau than patients without cognitive impairment. We concluded that positive CSF Aβ 42 with negative Aβ 42 /Aβ 40 , p-tau, and t-tau is a typical CSF profile of iNPH. On the contrary, positive Aβ 42 /Aβ 40 in iNPH patients, especially when associated with positive p-tau, may lead to suspicion of a coexistent AD pathology.
Databáze:	MEDLINE
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