| Autor: |
Barbalinardo M; National Research Council, Institute for the Study of Nanostructured Materials (CNR-ISMN), Via P. Gobetti 101, 40129 Bologna, Italy., Giannelli M; National Research Council, Institute for Organic Synthesis and Photoreactivity (CNR-ISOF), Via P. Gobetti 101, 40129 Bologna, Italy., Forcini L; National Research Council, Institute for Organic Synthesis and Photoreactivity (CNR-ISOF), Via P. Gobetti 101, 40129 Bologna, Italy., Luppi B; Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy., Donnadio A; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy., Navacchia ML; National Research Council, Institute for Organic Synthesis and Photoreactivity (CNR-ISOF), Via P. Gobetti 101, 40129 Bologna, Italy., Ruani G; National Research Council, Institute for the Study of Nanostructured Materials (CNR-ISMN), Via P. Gobetti 101, 40129 Bologna, Italy., Sotgiu G; National Research Council, Institute for Organic Synthesis and Photoreactivity (CNR-ISOF), Via P. Gobetti 101, 40129 Bologna, Italy., Aluigi A; Department of Biomolecular Sciences, School of Pharmacy, University of Urbino, Piazza del Rinascimento 06, 61029 Urbino (PU), Italy., Zamboni R; National Research Council, Institute for Organic Synthesis and Photoreactivity (CNR-ISOF), Via P. Gobetti 101, 40129 Bologna, Italy., Posati T; National Research Council, Institute for Organic Synthesis and Photoreactivity (CNR-ISOF), Via P. Gobetti 101, 40129 Bologna, Italy. |
| Abstrakt: |
Skin disorders are widespread around the world, affecting people of all ages, and oxidative stress represents one of the main causes of alteration in the normal physiological parameters of skin cells. In this work, we combined a natural protein, fibroin, with antioxidant compounds extracted in water from pomegranate waste. We demonstrate the effective and facile fabrication of bioactive and eco-sustainable films of potential interest for skin repair. The blended films are visually transparent (around 90%); flexible; stable in physiological conditions and in the presence of trypsin for 12 days; able to release the bioactive compounds in a controlled manner; based on Fickian diffusion; and biocompatible towards the main skin cells, keratinocytes and fibroblasts. Furthermore, reactive oxygen species (ROS) production tests demonstrated the high capacity of our films to reduce the oxidative stress induced in cells, which is responsible for various skin diseases. |
