Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations-Proof of Concept Study for Prediction of Clinical Outcome.

Autor: Gerwing M; Clinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany., Schindler P; Clinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany., Schneider KN; Department of Orthopedics and Tumor Orthopedics, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany., Sundermann B; Clinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany.; Evangelisches Krankenhaus Oldenburg, Medical Campus University of Oldenburg, 26122 Oldenburg, Germany.; Research Centre Neurosensory Science, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany., Köhler M; Clinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany., Stamm AC; Clinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany., Schmidt VF; Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany., Perkowski S; Clinic for Pediatric and Neonatal Surgery, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany., Deventer N; Department of Orthopedics and Tumor Orthopedics, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany., Heindel WL; Clinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany., Wildgruber M; Clinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany.; Department of Radiology, University Hospital, LMU Munich, 80336 Munich, Germany., Masthoff M; Clinic for Radiology, University of Muenster and University Hospital of Muenster, 48149 Muenster, Germany.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2022 Jun 09; Vol. 12 (6). Date of Electronic Publication: 2022 Jun 09.
DOI: 10.3390/diagnostics12061430
Abstrakt: Prediction of response to percutaneous sclerotherapy in patients with venous malformations (VM) is currently not possible with baseline clinical or imaging characteristics. This prospective single-center study aimed to predict treatment outcome of percutaneous sclerotherapy as measured by quality of life (QoL) by using radiomic analysis of diffusion-weighted (dw) magnetic resonance imaging (MRI) before and after first percutaneous sclerotherapy. In all patients ( n = 16) pre-interventional (PRE-) and delta (DELTA-) radiomic features (RF) were extracted from dw-MRI before and after first percutaneous sclerotherapy with ethanol gel or polidocanol foam, while QoL was assessed using the Toronto Extremity Salvage Score (TESS) and the 36-Item Short Form Survey (SF-36) health questionnaire. For selecting features that allow differentiation of clinical response, a stepwise dimension reduction was performed. Logistic regression models were fitted and selected PRE-/DELTA-RF were tested for their predictive value. QoL improved significantly after percutaneous sclerotherapy. While no common baseline patient characteristics were able to predict response to percutaneous sclerotherapy, the radiomics signature of VMs (independent PRE/DELTA-RF) revealed high potential for the prediction of clinical response after percutaneous sclerotherapy. This proof-of-concept study provides first evidence on the potential predictive value of (delta) radiomic analysis from diffusion-weighted MRI for Quality-of-Life outcome after percutaneous sclerotherapy in patients with venous malformations.
Databáze: MEDLINE
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