Long-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada.

Autor: Zhao N; Division of Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada., Smargiassi A; Département de Santé Environnementale Et de Santé Au Travail, School of Public Health, Université de Montréal, Montréal, QC, Canada.; Institut National de Santé Publique du Québec, Montréal, QC, Canada.; Centre of Public Health Research, University of Montreal and CIUSSS du Centre-Sud-de-L'Île-de-Montréal, Montreal, Canada., Jean S; Centre of Public Health Research, University of Montreal and CIUSSS du Centre-Sud-de-L'Île-de-Montréal, Montreal, Canada.; Université Laval and Bureau d'information Et d'études en Santé Des Populations, Institut National de Santé Publique du Québec (INSPQ), 945, avenue Wolfe, Québec, QC, G1V 5B3, Canada., Gamache P; Centre of Public Health Research, University of Montreal and CIUSSS du Centre-Sud-de-L'Île-de-Montréal, Montreal, Canada., Laouan-Sidi EA; Centre of Public Health Research, University of Montreal and CIUSSS du Centre-Sud-de-L'Île-de-Montréal, Montreal, Canada., Chen H; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.; Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.; Public Health Ontario, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Goldberg MS; Division of Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada.; Department of Medicine, McGill University, Québec, Canada., Bernatsky S; Division of Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada. sasha.bernatsky@mcgill.ca.; Department of Medicine, McGill University, Québec, Canada. sasha.bernatsky@mcgill.ca.; Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada. sasha.bernatsky@mcgill.ca.; Centre for Outcomes Research & Evaluation, Research Institute of the McGill University Health Centre, 5252 Boul. de Maisonneuve Ouest, (3F.51), Montreal, QC, H4A 3S5, Canada. sasha.bernatsky@mcgill.ca.
Jazyk: angličtina
Zdroj: Arthritis research & therapy [Arthritis Res Ther] 2022 Jun 23; Vol. 24 (1), pp. 151. Date of Electronic Publication: 2022 Jun 23.
DOI: 10.1186/s13075-022-02843-5
Abstrakt: Objectives: To estimate associations between fine particulate matter (PM 2.5 ) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs).
Methods: An open cohort of over 6 million adults was constructed from provincial physician billing and hospitalization records between 2000 and 2013. We defined incident SARD cases (SLE, Sjogren's syndrome, scleroderma, polymyositis, dermatomyositis, polyarteritis nodosa and related conditions, polymyalgia rheumatic, other necrotizing vasculopathies, and undifferentiated connective tissue disease) based on at least two relevant billing diagnostic codes (within 2 years, with at least 1 billing from a rheumatologist), or at least one relevant hospitalization diagnostic code. Estimated PM 2.5 and ozone concentrations (derived from remote sensing and/or chemical transport models) were assigned to subjects based on residential postal codes, updated throughout follow-up. Cox proportional hazards models with annual exposure levels were used to calculate hazard ratios (HRs) for SARDs incidence, adjusting for sex, age, urban-versus-rural residence, and socioeconomic status.
Results: The adjusted HR for SARDS related to one interquartile range increase in PM 2.5 (3.97 µg/m 3 ) was 1.12 (95% confidence interval 1.08-1.15), but there was no clear association with ozone. Indirectly controlling for smoking did not alter the findings.
Conclusions: We found associations between SARDs incidence and PM 2.5 , but no relationships with ozone. Additional studies are needed to better understand interplays between the many constituents of air pollution and rheumatic diseases.
(© 2022. The Author(s).)
Databáze: MEDLINE
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