Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management.
| Autor: | Yousaf A; Department of Molecular Pathology, Pakistan Kidney and Liver Institute & Research Center, Lahore, Pakistan., Sulong S; Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia., Abdullah B; Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia., Lazim NM; Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Medeniyet medical journal [Medeni Med J] 2022 Jun 23; Vol. 37 (2), pp. 194-202. |
| DOI: | 10.4274/MMJ.galenos.2022.63139 |
| Abstrakt: | Salivary gland neoplasms (SGNs) are rare and heterogeneous tumors in the head and neck region. Although progress has been recently made in revealing the molecular landscape of salivary glands tumors, it is limited and appears to be the tip of the iceberg. Some genetic aberrations include chromosomal translocations, such as CRTC1/3-MAML2 in mucoepidermoid carcinoma, g MYB-NFIB gene fusions in adenoid cystic carcinoma, and PLAG1-HMGA2 gene changes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma. These chromosomal translocations provide fresh insights into the molecular etiology of diverse SGNs and aid in their classification and in approaching treatment. In future, these genetic variations may serve as critical tools for diagnosing salivary gland tumors and optimizing the management as well as prognosis of patients. This review presents the most recent advances in the molecular pathology of salivary gland cancers, with an emphasis on distinguishing molecular features that can be used for optimizing current patient management. Competing Interests: Conflict of Interest: The authors have no conflict of interest to declare. (©Copyright 2022 by the Istanbul Medeniyet University / Medeniyet Medical Journal published by Galenos Publishing House.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|