Middle cerebral artery velocity is associated with the severity of MRI brain injury in neonates received therapeutic hypothermia.

Autor:	Ho SY; Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chiang MC; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Group of Integrated Care for Neonatal Neurological Disorders, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Study Group of Intensive and Integrated Care for Pediatric Central Nervous System (iCNS Group), Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: newborntw@gmail.com., Lin JJ; Division of Pediatric Critical Care Medicine and Pediatric Neurocritical Care Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Group of Integrated Care for Neonatal Neurological Disorders, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Study Group of Intensive and Integrated Care for Pediatric Central Nervous System (iCNS Group), Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: lin0227@adm.cgmh.org.tw., Chou IJ; Division of Pediatric Neurology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Group of Integrated Care for Neonatal Neurological Disorders, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Study Group of Intensive and Integrated Care for Pediatric Central Nervous System (iCNS Group), Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lee CC; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Group of Integrated Care for Neonatal Neurological Disorders, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Diane Mok TY; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lai MY; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Group of Integrated Care for Neonatal Neurological Disorders, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Wu IH; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Mun-Ching Wong A; Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Wang HS; Division of Pediatric Neurology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Study Group of Intensive and Integrated Care for Pediatric Central Nervous System (iCNS Group), Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lin KL; Division of Pediatric Neurology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Group of Integrated Care for Neonatal Neurological Disorders, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Study Group of Intensive and Integrated Care for Pediatric Central Nervous System (iCNS Group), Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Jazyk:	angličtina
Zdroj:	Biomedical journal [Biomed J] 2021 Dec; Vol. 44 (6 Suppl 1), pp. S119-S125. Date of Electronic Publication: 2020 Aug 08.
DOI:	10.1016/j.bj.2020.08.002
Abstrakt:	Background: No previous study has investigated the relationship between middle cerebral artery (MCA) flow velocity and the severity of hypoxic ischemic encephalopathy (HIE) evaluated by magnetic resonance imaging (MRI). The aim of this study was to assess the correlation between cerebral blood flow as assessed by transcranial Doppler sonography and the severity of MRI brain injury in asphyxiated neonates with clinical HIE who received therapeutic hypothermia. Methods: This retrospective cohort study was conducted in the neonatal intensive care unit at Chang Gung Memorial Hospital between April 2011 and May 2014. All neonates with HIE who received therapeutic hypothermia, transcranial Doppler examinations, and brain MRI were eligible. Brain MRI was performed at 11 days of age (interquartile range: 8.5-15 days) and the severity of MRI brain injuries was evaluated using the MR scoring system proposed by Barkovich et al. Serial transcranial Doppler examinations were performed in pre-hypothermia, hypothermia, and post-hypothermia phases. Results: Twenty-six neonates met the eligibility criteria for this study. Neonates with an abnormal MCA mean flow velocity (MFV) during the hypothermia phase had a higher risk of brain MRI abnormalities (77.8% vs. 22.2%, p = 0.017) and neonates with abnormal high MFV of MCA had higher MR scores of basal ganglia (p = 0.022). However, there were no statistical differences between abnormal MFV of MCA and brain MRI abnormalities during pre- and post-hypothermia phases. Conclusions: During therapeutic hypothermia, mean cerebral blood flow velocity of the MCA was associated with the severity of MRI brain injury in the neonates with clinical HIE. Competing Interests: Conflicts of interest All authors declare no conflicts of interest. (Copyright © 2020 Chang Gung University. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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