Green synthesis of 2-benzylidene-1-benzofuran-3-ones and in vitro neuraminidase study using molecular docking.

Autor: Devi AP; Department of Chemistry, School of Liberal Arts and Sciences, Mody University of Science and Technology, Lakshmangarh, India., Dhingra N; Department of Agriculture, Medi-CapsUniversity, Indore, India., Chundawat RS; Department of Biosciences, School of Liberal Arts and Sciences, Mody University of Science and Technology, Lakshmangarh, India., Ameta KL; Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, India.
Jazyk: angličtina
Zdroj: SAR and QSAR in environmental research [SAR QSAR Environ Res] 2022 Jul; Vol. 33 (7), pp. 499-512. Date of Electronic Publication: 2022 Jun 23.
DOI: 10.1080/1062936X.2022.2087733
Abstrakt: An improved and green method has been developed for the synthesis of substituted 2-benzylidene-1-benzofuran-3-ones by treating 2-hydroxychalcones with CuBr 2 in DMF-water mixture (7:3; v/v) using grinding methodology. Molecular docking and in vitro studies were also carried out, and it was revealed that compound #4h binds with the active amino Glu-277, Try-406 and Arg-152 of neuraminidase against influenza virus. Compound 4h exerts best inhibition activity (13 ± 1.8%) which was found similar to oseltamivir (12 ± 0.89%).
Databáze: MEDLINE
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