Field-based versus laboratory-based estimates of muscle quality index in adolescents with and without Down syndrome.

Autor: Melo GLR; Department of Physical Education, Catholic University of Brasília, Brasília, Brazil., Moraes MR; Department of Physical Education, Catholic University of Brasília, Brasília, Brazil., Nascimento EF; Department of Physical Education, Catholic University of Brasília, Brasília, Brazil.; Department of Physical Education, Secretary of the State of Education of the Federal District, Brasília, Brazil., Boato EM; Department of Physical Education, Secretary of the State of Education of the Federal District, Brasília, Brazil., Beal FLR; Department of Gerontology, Catholic University of Brasília, Brasília, Brazil., Stone W; Department of School of Kinesiology Recreation and Sport, Western Kentucky University, Bowling Green, FL, USA., da Cunha Nascimento D; Department of Physical Education, Catholic University of Brasília, Brasília, Brazil.; Department of Gerontology, Catholic University of Brasília, Brasília, Brazil.
Jazyk: angličtina
Zdroj: Journal of intellectual disability research : JIDR [J Intellect Disabil Res] 2022 Dec; Vol. 66 (12), pp. 1000-1008. Date of Electronic Publication: 2022 Jun 23.
DOI: 10.1111/jir.12959
Abstrakt: Background: Low muscle quality index (MQI) is a potential risk of developing functional impairments in older people. However, considering that individuals with Down syndrome (DS) present with a faster decline in biological aging, an investigation on MQI in individuals with DS is necessary. The aims of this present cross-sectional study were to compare (1) MQI between adolescents with and without DS and (2) evaluate laboratory versus field-based estimates of MQI.
Methods: Fifty-six adolescents were recruited and separated into two groups: DS (n = 30, 13 boys and 17 girls; age: 12.38 ± 3.07 years) and a control (non-DS; n = 26, 9 boys and 17 girls; age: 12.46 ± 2.88 years). Laboratory MQI was derived from the ratio of grip strength to arm muscle mass (in kg) measured by dual-energy X-ray absorptiometry (DXA). Field-based MQI was quantified from the ratio of hand grip strength (HGS) to body mass index (BMI). For statistical analyses, a two-way ANOVA was conducted for group comparisons, and a Pearson correlation was used to test the association between field MQI and laboratory MQI.
Results: Adolescents with DS displayed lower field (P = 0.001), laboratory MQI estimates (P = 0.001) and HGS (P = 0.001) as compared non-DS. Also, there was a strong correlation effect between field MQI and laboratory MQI estimates (P < 0.001, R = 0.81).
Conclusion: Adolescents with DS have lower field and laboratory MQI compared with adolescents without DS. Simpler field MQI might be used in daily clinical practice, with special attention to those with DS.
(© 2022 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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