Synthesis and Characterization of Novel [2 + 1] Tricarbonyl Rhenium Complexes with the Hydrophilic Phosphine Ligands PTA and CAP.

Autor: Roupa I; Institutes of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Flampouraris C; Institutes of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Shegani A; Institutes of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Ischyropoulou M; Institutes of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Makrypidi K; Institutes of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Raptopoulou C; Institutes of Nanoscience and Nanotechnology, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Pirmettis I; Institutes of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Papadopoulos MS; Institutes of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Psycharis V; Institutes of Nanoscience and Nanotechnology, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Chiotellis A; Institutes of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research 'Demokritos', 15310 Athens, Greece.
Jazyk: angličtina
Zdroj: Bioinorganic chemistry and applications [Bioinorg Chem Appl] 2022 Jun 13; Vol. 2022, pp. 3117661. Date of Electronic Publication: 2022 Jun 13 (Print Publication: 2022).
DOI: 10.1155/2022/3117661
Abstrakt: In the pursuit of hydrophilic model fac -[Re(CO) 3 ] + complexes for (radio) pharmaceutical applications, six novel [2 + 1] mixed-ligand complexes of the general type fac -[Re(CO) 3 (bid)P] were synthesized and characterized, where bid is a bidentate ligand bearing either (N, O) or (S, S') donor atom sets and P is the hydrophilic phosphine 1,3,5-triaza-7-phosphoadamantane (PTA) or its macrocyclic homologue 1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane (CAP). The (N, O) ligands used in this study were picolinic and quinaldic acid, while the (S, S') ligand was diethyldithiocarbamate. The complexes were synthesized in generally high yields and purity and the characterization was performed by spectroscopic methods, IR, NMR, and elemental analysis. Detailed X-ray crystallographic study of molecular packing by using Hirshfeld analysis tools revealed a plethora of intermolecular interactions such as hydrogen bond, π ⋯ π , C-H⋯ π , and carbonyl-carbonyl interactions. To our knowledge, the CAP complexes reported herein are the first example of [2 + 1] mixed-ligand fac -[Re(CO) 3 ] + complexes with CAP. The new complexes might have the potential to serve as platforms for the design of target-specific complexes with favorable pharmacokinetics.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2022 Ioanna Roupa et al.)
Databáze: MEDLINE
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