Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens.

Autor: Sakyi SA; Department of Molecular Medicine, School of Medical Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Wilson MD; Parasitology Department, Noguchi Memorial Institute for Medical Research College of Health Sciences, University of Ghana Legon Ghana., Adu B; Department of Immunology, Noguchi Memorial Institute for Medical Research College of Health Sciences, University of Ghana Legon Ghana., Opoku S; Department of Molecular Medicine, School of Medical Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.; Kumasi Center for Collaborative Research in Tropical Medicine Kumasi Ghana., Brewoo A; Department of Microbiology and Immunology, School of Medical Sciences University of Cape Coast Cape Ghana., Larbi A; Department of Biochemistry and Biotechnology Kwame Nkrumah University of Science and Technology Kumasi Ghana., Baafour EK; Department of Immunology, Noguchi Memorial Institute for Medical Research College of Health Sciences, University of Ghana Legon Ghana., Tchum SK; Kintampo Health Research Center, Ghana Health Service Kintampo-North Ghana., Saahene RO; Department of Microbiology and Immunology, School of Medical Sciences University of Cape Coast Cape Ghana., Aniagyei W; Department of Molecular Medicine, School of Medical Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.; Kumasi Center for Collaborative Research in Tropical Medicine Kumasi Ghana., Sewor C; Department of Biomedical Sciences, School of Allied Health Sciences University of Cape Coast Cape Coast Ghana., Courtin D; UMR 261 MERIT Institut de Recherche pour le Développement (IRD), Université de Paris Paris France., Cappello M; Partnerships for Global Health, Department of Pediatrics, Yale School of Medicine Yale University New Haven Connecticut USA., Gyan B; Department of Immunology, Noguchi Memorial Institute for Medical Research College of Health Sciences, University of Ghana Legon Ghana., Amoani B; Department of Biomedical Sciences, School of Allied Health Sciences University of Cape Coast Cape Coast Ghana.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2022 Jun 14; Vol. 5 (4), pp. e672. Date of Electronic Publication: 2022 Jun 14 (Print Publication: 2022).
DOI: 10.1002/hsr2.672
Abstrakt: Background: Plasmodium falciparum and Hookworm infections are prevalent in West Africa and they cause iron deficiency anemia and protein malnutrition in Children. Immune response of these parasites interact and their interactions could have repercussions on vaccine development and efficacy. The current goal of hookworm eradication lies on vaccination. We evaluated the effect of P. falciparum coinfection and albendazole treatment on naturally acquired antibody profile against hookworm L3 stage larvae antigen.
Methods: In a longitudinal study, 40 individuals infected with Necator americanus  only, 63 participants infected with N. americanus and P. falciparum , and 36 nonendemic controls (NECs) were recruited. The study was done in the Kintampo North Metropolis of Ghana. Stool and blood samples were taken for laboratory analyses. Serum samples were obtained before hookworm treatment and 3 weeks after treatment.
Results: The malaria-hookworm ( N. americanus and P. falciparum ) coinfected subjects had significantly higher levels of IgE ( β  = 0.30, 95% CI = [0.12, 0.48], p  = 0.023) and IgG3 ( β  = 0.15, 95% CI = [0.02, 0.52], p  = 0.004) compared to those infected with hookworm only ( N. americanus ). The N. americanus groups had significantly higher levels of IgG3 ( β  = 0.39, 95% CI = [0.14-0.62], p  = 0.002) compared to the control group. Similarly, N. americanus and P. falciparum coinfected participants had significantly higher levels of IgE ( β  = 0.35, 95% CI = [0.70-0.39], p  = 0.002) and IgG3 ( β  = 0.54, 95% CI = [0.22-0.76], p  = 0.002). Moreover, albendazole treatment led to a significant reduction in IgE, IgA, IgM, and IgG3 antibodies against hookworm L3 stage larvae ( p  < 0.05).
Conclusion: P. falciparum is associated with improved IgE and IgG response against hookworm L3 stage larvae. Treatment with single dose of albendazole led to reduction in naturally acquired immune response against hookworm infection. Thus, P. falciparum infection may have a boosting effect on hookworm vaccine effectiveness.
Competing Interests: The authors declare no conflict of interest.
(© 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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