Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy.
| Autor: | Szu JI; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United States., Binder DK; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cellular neuroscience [Front Cell Neurosci] 2022 Jun 06; Vol. 16, pp. 900588. Date of Electronic Publication: 2022 Jun 06 (Print Publication: 2022). |
| DOI: | 10.3389/fncel.2022.900588 |
| Abstrakt: | Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms underlying seizure activity have been intensely investigated. Alterations in astrocytic channels and transporters have shown to be a critical player in seizure generation and epileptogenesis. One key protein involved in such processes is the astrocyte water channel aquaporin-4 (AQP4). Studies have revealed that perivascular AQP4 redistributes away from astrocyte endfeet and toward the neuropil in both clinical and preclinical studies. This subcellular mislocalization significantly impacts neuronal hyperexcitability and understanding how AQP4 becomes dysregulated in epilepsy is beginning to emerge. In this review, we evaluate the role of AQP4 dysregulation and mislocalization in epilepsy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Szu and Binder.) |
| Databáze: | MEDLINE |
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