Bioavailability and biotransformation of linolenic acid from basil seed oil as a novel source of omega-3 fatty acids tested on a rat experimental model.

Autor: Martínez R; Cellbitec S.L., N.I.F. B04847216, Scientific Headquarters of the Almería Technology Park, Universidad de Almería, 04128 La Cañada, Almería, Spain. rosario.martinez@cellbitec.com.; Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Center (CIBM), Universidad de Granada, 18100 Granada, Spain. mlopezj@ugr.es., Mesas C; Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain. cristinam@ugr.es.; Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain., Guzmán A; Cellbitec S.L., N.I.F. B04847216, Scientific Headquarters of the Almería Technology Park, Universidad de Almería, 04128 La Cañada, Almería, Spain. rosario.martinez@cellbitec.com.; Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain. cristinam@ugr.es., Galisteo M; Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain. mgalist@ugr.es., López-Jurado M; Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Center (CIBM), Universidad de Granada, 18100 Granada, Spain. mlopezj@ugr.es., Prados J; Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain. cristinam@ugr.es.; Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain.; Instituto Biosanitario de Granada (ibs. GRANADA), 18014 Granada, Spain., Melguizo C; Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain. cristinam@ugr.es.; Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain.; Instituto Biosanitario de Granada (ibs. GRANADA), 18014 Granada, Spain., Bermúdez F; Cellbitec S.L., N.I.F. B04847216, Scientific Headquarters of the Almería Technology Park, Universidad de Almería, 04128 La Cañada, Almería, Spain. rosario.martinez@cellbitec.com., Porres JM; Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Center (CIBM), Universidad de Granada, 18100 Granada, Spain. mlopezj@ugr.es.
Jazyk: angličtina
Zdroj: Food & function [Food Funct] 2022 Jul 18; Vol. 13 (14), pp. 7614-7628. Date of Electronic Publication: 2022 Jul 18.
DOI: 10.1039/d2fo00672c
Abstrakt: Basil is an aromatic herb with a high concentration of bioactive compounds. The oil extracted from its seeds is a good source of α-linolenic acid (ALA) and also provides substantial amounts of linoleic acid (LA). This study aimed to test the bioavailability of the oil derived from basil seeds and its effects on different physiological parameters using 7-15% dietary inclusion levels. Furthermore, the assimilation of LA and ALA and their transformation in long-chain polyunsaturated fatty acids (LC-PUFAs) have been studied. Digestive utilization of total fat from basil seed oil (BSO) was high and similar to that of olive oil used as a control. Consumption of BSO resulted in increased LA and ALA levels of the plasma, liver, and erythrocyte membrane. In addition, the transformation of LA to arachidonic acid (ARA) was decreased by the high dietary intake of ALA which redirected the pathway of the Δ-6 desaturase enzyme towards the transformation of ALA into eicosapentaenoic acid (EPA). No alterations of hematological and plasma biochemical parameters were found for the 7 and 10% dietary inclusion levels of BSO, whereas a decrease in the platelet count and an increase in total- and HDL-cholesterol as well as plasma alkaline phosphatase (ALP) were found for a 15% BSO dose. In conclusion, BSO is a good source of ALA to be transformed into EPA and decrease the precursor of the pro-inflammatory molecule ARA. This effect on the levels of EPA in different tissues offers potential for its use as a dietary supplement, novel functional food, or a constituent of nutraceutical formulations to treat different pathologies.
Databáze: MEDLINE
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