Investigation of white blood cell characteristics in cerebrospinal fluid samples at pediatric brain tumor diagnosis.

Autor: Greer HR; University of Colorado School of Medicine, 13001 East 17th Place, Aurora, CO, 80045, USA., Miller K; University of Colorado School of Medicine, 13001 East 17th Place, Aurora, CO, 80045, USA., Samay S; Children's Hospital Colorado, 13123 East 16th Avenue, Aurora, CO, 80045, USA., Nellan A; Pediatric Oncology Branch, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD, 20892, USA., Green AL; Children's Hospital Colorado, University of Colorado School of Medicine, 13001 East 17th Place, Aurora, CO, 80045, USA. adam.green@cuanschutz.edu.
Jazyk: angličtina
Zdroj: Journal of neuro-oncology [J Neurooncol] 2022 Sep; Vol. 159 (2), pp. 301-308. Date of Electronic Publication: 2022 Jun 22.
DOI: 10.1007/s11060-022-04065-w
Abstrakt: Purpose: The role of white blood cells (WBC) in the pediatric central nervous system (CNS) tumor microenvironment is incompletely defined. We hypothesized that the WBC profile in cerebrospinal fluid (CSF) correlates with the presence of tumor cells and prognosis in pediatric CNS tumors, as well as other patient and disease characteristics, and differs by tumor type, thus giving insight into the tumor immune response.
Methods: We conducted a retrospective analysis of CSF WBC profiles at CNS tumor diagnosis in 269 patients at our institution. We examined total nucleated cell count, absolute counts, and percentages by WBC subtype. We compared CSF WBC values by tumor cell presence, patient vital status, tumor location, and the most common tumor types.
Results: Patients who died of their tumor had a lower CSF lymphocyte percentage and a higher absolute monocyte count in CSF at diagnosis. The presence of tumor cells in CSF was associated with fewer lymphocytes and monocytes. Ventricular tumors had higher CSF lymphocyte, monocyte, macrophage, and total nucleated cell counts than extraventricular tumors. Germ cell tumors, low-grade glioma, high-grade glioma, and ependymoma had lower macrophage counts or percentages compared to other tumor types.
Conclusions: WBC profile in CSF at pediatric CNS tumor diagnosis correlates with patient prognosis and presence of metastatic cells, along with tumor type and other tumor characteristics like relationship to the ventricles. Prospective CSF profiling and study may be useful to future immunotherapy and other pediatric CNS tumor clinical trials.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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