Pitfalls of iron supplementation in parenteral nutrition admixtures for children with intestinal failure.

Autor: Herdes RE; Stanford University School of Medicine, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Stanford, California, USA., Oliveira SB; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Kocoshis SA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Bernieh A; Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Namjoshi SS; Stanford University School of Medicine, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Stanford, California, USA.
Jazyk: angličtina
Zdroj: JPEN. Journal of parenteral and enteral nutrition [JPEN J Parenter Enteral Nutr] 2022 Nov; Vol. 46 (8), pp. 1944-1947. Date of Electronic Publication: 2022 Jul 09.
DOI: 10.1002/jpen.2428
Abstrakt: Background: Pediatric patients with intestinal failure are at increased risk for iron deficiency. Supplementation is not routinely included in parenteral nutrition solutions. There is currently limited research related to the safety of iron supplementation in parenteral nutrition and for intravenous forms used in patients with intestinal failure. Current American Society for Parenteral and Enteral Nutrition and ESPGHAN guidelines promote the use of enteral iron, acknowledging the risks of using iron supplementation within parenteral nutrition admixtures.
Methods: We review a patient case and the current available literature related to iron in parenteral nutrition.
Results: Five major concerns are identified: peroxidation reactions, incompatibility, hypersensitivity, infection risk, and iron overload.
Conclusion: We propose an argument against the preferential use of iron supplementation within parenteral nutrition in children with intestinal failure when enteral supplementation or intermittent parenteral infusion may be sufficient.
(© 2022 American Society for Parenteral and Enteral Nutrition.)
Databáze: MEDLINE
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