Controversial role of γδ T cells in pancreatic cancer.

Autor: Nezhad Shamohammadi F; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Yazdanifar M; Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA., Oraei M; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran., Kazemi MH; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran., Roohi A; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran., Mahya Shariat Razavi S; Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM, USA., Rezaei F; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran., Parvizpour F; Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran., Karamlou Y; Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran., Namdari H; Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: H_namdari29@yahoo.com.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2022 Jul; Vol. 108, pp. 108895. Date of Electronic Publication: 2022 May 31.
DOI: 10.1016/j.intimp.2022.108895
Abstrakt: γδ T cells are rare lymphocytes with cogent impact on immune responses. These cells are one of the earliest cells to be recruited in the sites of infection or tumors and play a critical role in coordinating innate and adaptive immune responses. The anti-tumor activity of γδ T cells have been numerously reported; nonetheless, there is controversy among published studies regarding their anti-tumor vs pro-tumor effect- especially in pancreatic cancer. A myriad of studies has confirmed that activated γδ T cells can potently lyse a broad variety of solid tumors and leukemia/lymphoma cells and produce an array of cytokines; however, early γδ T cell-based clinical trials did not lead to optimal efficacy, despite acceptable safety. Depending on the local micromilieu, γδ T cells can differentiate into tumor promoting or suppressing cells such as Th1-, Th2-, or Th17-like cells and produce prototypical cytokines such as interferon-γ (IFNγ) and interleukin (IL)-4/-10, IL-9, or IL-17. In an abstruse tumor such as pancreatic cancer- also known as immunologically cold tumor- γδ T cells are more likely to switch to their immunosuppressive phenotype. In this review we will adduce the accumulated knowledge on these two controversial aspects of γδ T cells in cancers- with a focus on solid tumors and pancreatic cancer. In addition, we propose strategies for enhancing the anti-tumor function of γδ T cells in cancers and discuss the potential future directions.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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